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Details on Person VRAC heteromer transports I-, Cl- from cytosol to extracellular region

Class:Id	Reaction:8941543
_displayName	VRAC heteromer transports I-, Cl- from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2017-01-06 12:19:38
authored	[InstanceEdit:8941520] Jassal, Bijay, 2016-10-04
catalystActivity	[CatalystActivity:8941537] volume-sensitive anion channel activity of VRAC heteromer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8941520] Jassal, Bijay, 2016-10-04
edited	[InstanceEdit:8941520] Jassal, Bijay, 2016-10-04
input	[DefinedSet:8941540] I-, Cl- [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8941534] SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel [LiteratureReference:8941529] Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC [LiteratureReference:8941548] LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength [LiteratureReference:8941518] Volume-regulated anion channel--a frenemy within the brain [LiteratureReference:8941717] VRAC: molecular identification as LRRC8 heteromers with differential functions
modified	[InstanceEdit:8941713] Jassal, Bijay, 2016-10-06 [InstanceEdit:8941718] Jassal, Bijay, 2016-10-06 [InstanceEdit:8941748] Jassal, Bijay, 2016-10-06 [InstanceEdit:8954001] Jassal, Bijay, 2017-01-04 [InstanceEdit:8954280] Jassal, Bijay, 2017-01-06 [InstanceEdit:8954304] Jassal, Bijay, 2017-01-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VRAC heteromer transports I-, Cl- from cytosol to extracellular region
output	[DefinedSet:8941541] I-, Cl- [extracellular region]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8941561] R-HSA-8941543.2
summation	[Summation:8941714] Maintaining a constant cell volume in response to extracellu...
(hasEvent)	[Pathway:5223345] Miscellaneous transport and binding events [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
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No pathways have been reviewed or authored by VRAC heteromer transports I-, Cl- from cytosol to extracellular region (8941543)