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Details on Person Uridylyltransferases mediate the terminal uridylation of mRN...

Class:Id	Summation:8941308
_displayName	Uridylyltransferases mediate the terminal uridylation of mRN...
_timestamp	2023-01-31 03:42:20
created	[InstanceEdit:8941302] Jupe, Steve, 2016-09-30
literatureReference	[LiteratureReference:8961812] RNA decay via 3' uridylation [LiteratureReference:8961805] Emerging roles of RNA modification: m(6)A and U-tail [LiteratureReference:8961796] Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life [LiteratureReference:8960041] Uridine addition after microRNA-directed cleavage [LiteratureReference:8961818] Uridylation Earmarks mRNAs for Degradation… and More [LiteratureReference:8941305] Uridylation by TUT4 and TUT7 marks mRNA for degradation [LiteratureReference:8960045] TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications [LiteratureReference:8961821] TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA [LiteratureReference:8960046] The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation [LiteratureReference:8960055] Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5' [LiteratureReference:8960057] Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay [LiteratureReference:8960064] Deep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes [LiteratureReference:8961815] Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4) [LiteratureReference:8961807] Regulation of microRNA biogenesis [LiteratureReference:8961799] Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs [LiteratureReference:9820811] Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development
modified	[InstanceEdit:8941318] Jupe, Steve, 2016-09-30 [InstanceEdit:8960051] Jupe, Steve, 2017-02-02 [InstanceEdit:8960082] Jupe, Steve, 2017-02-02 [InstanceEdit:8961824] Jupe, Steve, 2017-02-06 [InstanceEdit:9820934] May, Bruce, 2022-11-21 [InstanceEdit:9820948] May, Bruce, 2022-11-21 [InstanceEdit:9827267] May, Bruce, 2023-01-31
text	Uridylyltransferases mediate the terminal uridylation of mRNAs, RISC-cleaved transcripts and of various non-coding RNAs including miRNAs and their precursors mRNAs (Scott and Norbury 2013, Lee et al. 2014, Munoz-Tello et al. 2015, Scheer et al. 2016). TUT4 and TUT7 (ZCCHC11, ZCCHC6) are mRNA uridylation enzymes that can act on the majority of mammalian mRNAs (Lim et al. 2014). More than 85% of mRNAs are uridylated at a frequency of higher than 1% in NIH 3T3 and HeLa cells (Chang et al. 2014). Uridylated tails were found mainly on mRNAs with polyA tails of less than 25 nucleotides, suggesting that uridylation may occur after deadenylation. There was a negative correlation between uridylation frequency and mRNA half‑life, suggesting a role of uridylation in general mRNA decay (Lim et al. 2014). TUT4 and TUT7 (ZCCHC11, ZCCHC6) also uridylate replication-dependent histone mRNAs, which are not polyadenylated, to facilitate their degradation (Lackey et al 2016, Schmidt et al. 2011, Mullen & Marzluff 2008, Hoefig et al. 2013, Slevin et al. 2014). TUT4 and TUT7 also uridylate miRNAs and their precursors (Thornton et al. 2014, Lee et al. 2014, Ha & Kim 2014). Mono-uridylation of pre-miRNA facilitates miRNA processing, while polyuridylation of pre-miRNA triggers their degradation (Heo et al. 2012). TUT4 and TUT7 are expressed during zygotic genome activation and uridylate the 3' ends of specific maternal mRNAs thereby targeting those mRNAs for degradation (inferred from mouse zygotes in Zhao et al. 2022). PABPN1L binds the terminal oligouridylate and recruits DIS3L2, a 3'-5' exoribonuclease (inferred from mouse zygotes in Zhao et al. 2022).
(summation)	[Reaction:8941312] TUT4,TUT7 oligouridylate mRNA [Homo sapiens]
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