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Details on Person Interleukin-36 receptor antagonist protein (IL36RN, IL-36Ra)...

Class:IdSummation:8940996
_displayNameInterleukin-36 receptor antagonist protein (IL36RN, IL-36Ra)...
_timestamp2017-03-13 16:59:37
created[InstanceEdit:8940993] Jupe, Steve, 2016-09-29
literatureReference[LiteratureReference:8940999] Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity
[LiteratureReference:8941492] Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
[LiteratureReference:8941506] Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis
[LiteratureReference:8863040] IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
modified[InstanceEdit:8941003] Jupe, Steve, 2016-09-29
[InstanceEdit:8941324] Jupe, Steve, 2016-09-30
[InstanceEdit:8941505] Jupe, Steve, 2016-10-04
[InstanceEdit:8981679] Jupe, Steve, 2017-03-13
textInterleukin-36 receptor antagonist protein (IL36RN, IL-36Ra) binds the interleukin-36 receptor subunit IL1RL2 (Interleukin-1 receptor-like 2, IL-1Rrp2). This inhibits the activity of interleukin-36 (IL36) by preventing IL1RL2 and IL1RAP from associating to form the interleukin-36 receptor complex (Towne et al. 2015). Similarly, Interleukin-1 family member 10 (IL1F10), also referred to as Interleukin-38, binds the interleukin-36 receptor subunit IL1RL2 inhibiting IL36 signaling (van de Veerdonk et al. 2012). Homozygous and compound heterozygous mutations in IL36RN have been identified to cause generalized pustular psoriasis (GPP) (Onoufriadis et al. 2011, Marrakchi et al. 2011).
(summation)[Reaction:8940998] IL36RN, IL1F10 bind IL1RL2 [Homo sapiens]
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