Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person FOLR2 binds FOLA

Class:IdReaction:8940134
_displayNameFOLR2 binds FOLA
_doReleaseTRUE
_timestamp2025-08-12 22:17:58
authored[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
catalystActivity[CatalystActivity:9954163] folic acid receptor activity of FOLR2 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9954164] folic acid receptor activity of FOLR2 [plasma membrane] Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
edited[InstanceEdit:8940132] Jassal, Bijay, 2016-09-23
input[SimpleEntity:200716] FOLA [extracellular region]
[EntityWithAccessionedSequence:8940133] FOLR2 [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9954854] D'Eustachio, Peter, 2025-06-09
isChimericFALSE
literatureReference[LiteratureReference:8940113] Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA
[LiteratureReference:8940120] Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
[LiteratureReference:8940121] Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells
modified[InstanceEdit:8940360] Jassal, Bijay, 2016-09-26
[InstanceEdit:8942348] Jassal, Bijay, 2016-10-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9954162] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9954853] D'Eustachio, Peter, 2025-06-09
[InstanceEdit:9962971] D'Eustachio, Peter, 2025-08-12
nameFOLR2 binds FOLA
output[Complex:8940118] FOLR2:FOLA [plasma membrane] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-12-12
reviewed[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
[InstanceEdit:9962972] Hill, David P, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8940136] R-HSA-8940134.3
structureModified[InstanceEdit:9954162] D'Eustachio, Peter, 2025-06-06
summation[Summation:8940361] The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) b...
(hasEvent)[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(precedingEvent)[BlackBoxEvent:8942344] FOLR2 transports FOLA from extracellular region to cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964647] Update Tracker - [Reaction:8940134] FOLR2 binds FOLA - v94:[removeCatalystActivity]
[Change default viewing format]
No pathways have been reviewed or authored by FOLR2 binds FOLA (8940134)
Follow Reactome