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Details on Person NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+

Class:Id	Reaction:8939959
_displayName	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+
_doRelease	TRUE
_timestamp	2025-07-27 08:26:06
authored	[InstanceEdit:8939958] Jassal, Bijay, 2016-09-22
catalystActivity	[CatalystActivity:8939960] nicotinamide-nucleotide adenylyltransferase activity of NMNAT2:Mg2+ [Golgi membrane]
compartment	[Compartment:70101] cytosol [Compartment:20699] Golgi membrane
created	[InstanceEdit:8939958] Jassal, Bijay, 2016-09-22
crossReference	[DatabaseIdentifier:9938183] RHEA:21361
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
input	[SimpleEntity:8869353] NMN [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
literatureReference	[LiteratureReference:200498] Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms [LiteratureReference:9938154] Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases [LiteratureReference:200490] Identification of a novel human nicotinamide mononucleotide adenylyltransferase [LiteratureReference:200485] Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis [LiteratureReference:197244] Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas
modified	[InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:8940091] Jassal, Bijay, 2016-09-23 [InstanceEdit:8942352] Jassal, Bijay, 2016-10-13 [InstanceEdit:8943459] Jassal, Bijay, 2016-10-25 [InstanceEdit:9655301] D'Eustachio, Peter, 2019-07-24 [InstanceEdit:9748648] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10 [InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11 [InstanceEdit:9961849] May, Bruce, 2025-07-27
name	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+)
output	[SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:8869633] NMRK1 phosphorylates NR to yield NMN [Homo sapiens] [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN [Homo sapiens] [Reaction:9961787] NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi) [Homo sapiens] [BlackBoxEvent:9961792] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14 and H4K16ac:NAMPT gene positively regulates expression of NAMPT [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-12-12
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8939961] R-HSA-8939959.6
structureModified	[InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10
summation	[Summation:197257] NMNAT2 catalyzes the reaction of nicotinate D-ribonucleotide...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens] [Pathway:9958957] NAD+ and Sirtuins regulate the circadian clock [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9961806] NAD+ translocates from the cytosol to the nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775563] Update Tracker - [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - v78:[add_removeOutput] [_UpdateTracker:9777577] Update Tracker - [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - v70:[add_removeInput] [_UpdateTracker:9939661] Update Tracker - [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - v92:[modifyText, removeInput, removeLiteratureReference]
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