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Details on Person The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ...
| Class:Id | Summation:8939715 |
|---|---|
| _displayName | The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ... |
| _timestamp | 2017-08-09 15:03:21 |
| created | [InstanceEdit:8939716] Orlic-Milacic, Marija, 2016-09-21 |
| modified | [InstanceEdit:9015289] Orlic-Milacic, Marija, 2017-08-09 |
| text | The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates RUNX2 on unknown lysine residues, targeting it for proteasome-mediated degradation. SKP2-triggered RUNX2 degradation negatively regulates osteogenesis by inhibiting differentiation of osteoblasts (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015). |
| (summation) | [Reaction:8939706] SCF(SKP2) polyubiquitinates RUNX2 [Homo sapiens] |
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No pathways have been reviewed or authored by The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ... (8939715)
