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Details on Person SCF(SKP2) polyubiquitinates RUNX2

Class:Id	Reaction:8939706
_displayName	SCF(SKP2) polyubiquitinates RUNX2
_doRelease	TRUE
_timestamp	2018-12-18 19:52:17
authored	[InstanceEdit:8939907] Orlic-Milacic, Marija, 2016-09-21
catalystActivity	[CatalystActivity:8939717] ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643203] ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939709] Orlic-Milacic, Marija, 2016-09-21
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
input	[Complex:8939702] RUNX2:SCF(SKP2) [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8939697] Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 [LiteratureReference:9015268] Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation
modified	[InstanceEdit:8939718] Orlic-Milacic, Marija, 2016-09-21 [InstanceEdit:9008130] Orlic-Milacic, Marija, 2017-06-07 [InstanceEdit:9014260] Orlic-Milacic, Marija, 2017-07-27 [InstanceEdit:9015289] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015315] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015317] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9632446] Rothfels, Karen, 2018-12-18 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF(SKP2) polyubiquitinates RUNX2
output	[Complex:8939693] SCF (SKP2) complex [nucleoplasm] [Homo sapiens] [CandidateSet:9008122] PolyUb-RUNX2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8939688] SCF(SKP2) complex binds RUNX2 [Homo sapiens] [BlackBoxEvent:9007999] RUNX2 translocates to the nucleus [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8939713] R-HSA-8939706.4
summation	[Summation:8939715] The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ...
(hasEvent)	[Pathway:8939902] Regulation of RUNX2 expression and activity [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8939801] 26S proteasome degrades PolyUb-RUNX2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777944] Update Tracker - [Reaction:8939706] SCF(SKP2) polyubiquitinates RUNX2 - v68:[add_removeInput]
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No pathways have been reviewed or authored by SCF(SKP2) polyubiquitinates RUNX2 (8939706)