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Details on Person UniProt:Q9H334-8 FOXP1
| Class:Id | ReferenceIsoform:8939383 |
|---|---|
| _chainChangeLog | chain:1-677 added on Fri February 6 2015;chain:1-692 removed on Fri November 4 2016;chain:1-677 added on Fri November 4 2016 |
| _displayName | UniProt:Q9H334-8 FOXP1 |
| _timestamp | 2026-02-20 22:32:22 |
| chain | chain:1-677 |
| checksum | AEE92D47BB20964B |
| comment | FUNCTION Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735).FUNCTION Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).SUBUNIT Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308). Interacts with TBR1 (PubMed:30250039). Interacts with AURKA; this interaction facilitates the phosphorylation of FOXP1, which suppresses the expression of FBXL7 (PubMed:28218735). Interacts with ZMYM2 (PubMed:32891193).INTERACTION Not found in the nucleolus.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Isoform 8 is specifically expressed in embryonic stem cells.INDUCTION By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.DOMAIN The leucine zipper (ZIP) is required for dimerization and transcriptional repression.DISEASE A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Incomplete sequence.MISCELLANEOUS Incomplete sequence.MISCELLANEOUS May be due to competing acceptor splice site.SEQUENCE CAUTION Aberrant splicing. |
| created | [InstanceEdit:8939360] May, Bruce, 2016-09-18 |
| crossReference | [DatabaseIdentifier:8939377] NCBI Nucleotide:NM_001244810 |
| description | recommendedName: Forkhead box protein P1 alternativeName: fullName evidence="24"Mac-1-regulated forkhead shortName evidence="24"MFH |
| geneName | FOXP1 HSPC215 |
| identifier | Q9H334 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromosomal rearrangement Disease variant DNA-binding Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FOXP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8939358] ENSEMBL:ENSG00000114861 FOXP1 [Homo sapiens] |
| secondaryIdentifier | FOXP1_HUMAN A3QVP8 B3KV70 G5E9V8 Q8NAN6 Q9BSG9 Q9H332 Q9H333 Q9P0R1 |
| sequenceLength | 677 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9H334-8 |
| (referenceEntity) | [EntityWithAccessionedSequence:8939362] FOXP1-ES [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H334-8 FOXP1 (8939383)
