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Details on Person RNF170:ERLIN1:ERLIN2 binds ITPR1 (IP(3) receptor) and Ubiquitin:UBE2D2

Class:Id	Reaction:8939325
_displayName	RNF170:ERLIN1:ERLIN2 binds ITPR1 (IP(3) receptor) and Ubiquitin:UBE2D2
_timestamp	2016-10-16 12:51:27
authored	[InstanceEdit:8939320] May, Bruce, 2016-09-17
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:8939339] May, Bruce, 2016-09-18
edited	[InstanceEdit:8939320] May, Bruce, 2016-09-17
input	[Complex:8939316] RNF170:ERLIN1:ERLIN2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3006433] ITPR1 [endoplasmic reticulum membrane] [Homo sapiens] [Complex:8939330] Ub:UBE2D2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8939337] RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation [LiteratureReference:8942479] A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling
modified	[InstanceEdit:8942163] May, Bruce, 2016-10-08 [InstanceEdit:8942484] May, Bruce, 2016-10-16
name	RNF170:ERLIN1:ERLIN2 binds ITPR1 (IP(3) receptor) and Ubiquitin:UBE2D2
output	[Complex:8939321] RNF170:ERLIN1:ERLIN2:ITPR1:Ub:UBE2D2 [endoplasmic reticulum membrane] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8939340] R-HSA-8939325.1
summation	[Summation:8942148] The ubiquitin E3 ligase RNF170 located on the endoplasmic re...
(hasEvent)	[Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8939326] RNF170 polyubiquitinates ITPR1 (IP3R1, IP(3) receptor) [Homo sapiens]
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No pathways have been reviewed or authored by RNF170:ERLIN1:ERLIN2 binds ITPR1 (IP(3) receptor) and Ubiquitin:UBE2D2 (8939325)