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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Estrogen responsive signaling and Estrogen-responsive signaling in cancer

Class:IdPathwayDiagram:8939215
_displayNameDiagram of Estrogen responsive signaling and Estrogen-responsive signaling in cancer
_timestamp2023-08-22 16:55:20
created[InstanceEdit:8939214] Rothfels, Karen, 2016-09-16
height3175
modified[InstanceEdit:8944108] Rothfels, Karen, 2016-11-02
[InstanceEdit:8948211] Rothfels, Karen, 2016-11-11
[InstanceEdit:9009069] Rothfels, Karen, 2017-06-14
[InstanceEdit:9009393] Rothfels, Karen, 2017-06-16
[InstanceEdit:9009660] Rothfels, Karen, 2017-06-21
[InstanceEdit:9012004] Rothfels, Karen, 2017-07-06
[InstanceEdit:9012009] Rothfels, Karen, 2017-07-07
[InstanceEdit:9012229] Rothfels, Karen, 2017-07-11
[InstanceEdit:9012325] Rothfels, Karen, 2017-07-12
[InstanceEdit:9018344] Rothfels, Karen, 2017-08-30
[InstanceEdit:9018532] Rothfels, Karen, 2017-09-01
[InstanceEdit:9018645] Rothfels, Karen, 2017-09-01
[InstanceEdit:9022170] Rothfels, Karen, 2017-09-21
[InstanceEdit:9023889] Rothfels, Karen, 2017-09-28
[InstanceEdit:9024127] Rothfels, Karen, 2017-09-29
[InstanceEdit:9024145] Rothfels, Karen, 2017-09-29
[InstanceEdit:9028383] Rothfels, Karen, 2017-11-07
[InstanceEdit:9032758] Rothfels, Karen, 2017-12-18
[InstanceEdit:9036298] Rothfels, Karen, 2018-01-31
[InstanceEdit:9038031] Rothfels, Karen, 2018-02-22
[InstanceEdit:9038057] Rothfels, Karen, 2018-02-22
[InstanceEdit:9038122] Rothfels, Karen, 2018-02-22
[InstanceEdit:9038168] Rothfels, Karen, 2018-02-23
[InstanceEdit:9038171] Rothfels, Karen, 2018-02-23
[InstanceEdit:9632871] Rothfels, Karen, 2018-12-21
[InstanceEdit:9637843] Rothfels, Karen, 2019-02-20
[InstanceEdit:9637952] Rothfels, Karen, 2019-02-21
[InstanceEdit:9709548] Jassal, Bijay, 2020-12-15
[InstanceEdit:9709562] Jassal, Bijay, 2020-12-15
[InstanceEdit:9710002] Jassal, Bijay, 2020-12-21
[InstanceEdit:9710005] Jassal, Bijay, 2020-12-21
[InstanceEdit:9716963] Jassal, Bijay, 2021-03-02
[InstanceEdit:9763868] D'Eustachio, Peter, 2022-02-07
[InstanceEdit:9842204] Matthews, Lisa, 2023-08-22
representedPathway[Pathway:8939211] ESR-mediated signaling [Homo sapiens]
[Pathway:9011980] Estrogen-responsive signaling in cancer
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textPosition="3095 209" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GREB1 mRNA:miR-26 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="403" reactomeId="9011867" position="2311 206" bounds="2249 195 124 22" textPosition="2270 195"> <Properties> <displayName>miR-26 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="404" reactomeId="9011919" position="2467 907" bounds="2405 868 124 78" textPosition="2408 896" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>KDM4B gene:nucleoplasm:ESR1:ESTG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="419" reactomeId="9012178" position="2093 423" bounds="2031 398 124 51" textPosition="2056 425"> <Properties> <displayName>CHD1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="420" reactomeId="9012181" position="2139 209" bounds="2061 190 156 38" textPosition="2098 198"> <Properties> <displayName>CHD1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableGene id="423" reactomeId="9011672" position="2843 472" bounds="2803 440 81 65" textPosition="2804 467"> <Properties> <displayName>GREB1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="424" reactomeId="9011854" position="2886 272" bounds="2830 246 113 52" textPosition="2843 261"> <Properties> <displayName>GREB1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="428" reactomeId="9012183" position="2349 306" bounds="2287 288 124 36" textPosition="2291 288" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHD1 mRNA:mIR-26 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="431" reactomeId="9012174" position="2269 456" bounds="2236 445 66 22" textPosition="2248 445"> <Properties> <displayName>CHD1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="433" reactomeId="9012165" position="2682 457" bounds="2642 425 81 65" textPosition="2642 452"> <Properties> <displayName>KPNA2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="434" reactomeId="9012169" position="2658 245" bounds="2602 219 113 52" textPosition="2614 234"> <Properties> <displayName>KPNA2 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="436" reactomeId="9012172" position="2511 298" bounds="2456 273 110 50" textPosition="2465 287" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>KPNA2 mRNA:mIR-26 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="438" reactomeId="206045" position="2538 461" bounds="2498 450 81 22" textPosition="2514 450"> <Properties> <displayName>KPNA2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="441" reactomeId="9011626" position="3084 426" bounds="3044 415 81 22" textPosition="3061 415"> <Properties> <displayName>GREB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="447" reactomeId="9012290" position="3429 922" bounds="3367 862 124 120" textPosition="3367 904" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="450" reactomeId="9012291" position="3483 808" bounds="3421 790 124 36" textPosition="3424 804" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:ESTG:P-TEFb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="451" reactomeId="9012311" position="3700 801" bounds="3638 741 124 120" textPosition="3640 783" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="453" reactomeId="9012307" position="3529 618" bounds="3467 572 124 92" textPosition="3469 600" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYB gene:hypophosphorylated RNA polymerase II:TFIIF</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="455" reactomeId="29358" position="3749 930" bounds="3719 915 60 30" textPosition="3733 919" /> <org.gk.render.RenderableChemical id="456" reactomeId="113582" position="3620 951" bounds="3590 936 60 30" textPosition="3604 940"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableGene id="635" reactomeId="9018329" position="1447 2047" bounds="1407 2015 81 65" textPosition="1407 2042"> <Properties> <displayName>CXXC5 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="636" reactomeId="9018328" position="1229 2043" bounds="1167 2018 124 50" textPosition="1170 2032" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CXXC5 gene:ESR1:ESTG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="640" reactomeId="9018222" position="1343 2163" bounds="1303 2152 81 22" textPosition="1319 2152"> <Properties> <displayName>CXXC5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="672" reactomeId="9018486" position="2223 2139" bounds="2161 2121 124 36" textPosition="2171 2128"> <Properties> <displayName>TFF1, TFF3 gene</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="689" reactomeId="9018480" position="2617 2139" bounds="2555 2114 124 50" textPosition="2559 2128" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFF3 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="690" reactomeId="9018479" position="2874 2131" bounds="2812 2092 124 78" textPosition="2814 2120" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="697" reactomeId="9017893" position="2507 2283" bounds="2445 2258 124 51" textPosition="2473 2285"> <Properties> <displayName>TFF3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="699" reactomeId="9017888" position="2760 2954" bounds="2727 2943 66 22" textPosition="2742 2943"> <Properties> <displayName>TFF3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="714" reactomeId="9008284" position="2864 2274" bounds="2809 2256 110 36" textPosition="2824 2256" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1 dimer:estrogen</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="715" reactomeId="9009537" position="2856 2489" bounds="2794 2464 124 51" textPosition="2822 2491"> <Properties> <displayName>TFF1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="717" reactomeId="9009531" position="3121 2365" bounds="3059 2326 124 78" textPosition="3058 2368" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:TFF1 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="721" reactomeId="3900136" position="3205 2302" bounds="3172 2291 66 22" textPosition="3184 2291"> <Properties> <displayName>DDX5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="722" reactomeId="9009528" position="3328 2356" bounds="3266 2310 124 92" textPosition="3265 2352" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="724" reactomeId="83718" position="3443 2443" bounds="3417 2432 52 22" textPosition="3428 2432"> <Properties> <displayName>TBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="725" reactomeId="109629" position="3380 2453" bounds="3354 2442 52 22" textPosition="3362 2442" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFIIA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="726" reactomeId="9009538" position="3519 2362" bounds="3457 2316 124 92" textPosition="3456 2358" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="729" reactomeId="400139" position="3571 2276" bounds="3531 2265 81 22" textPosition="3546 2265"> <Properties> <displayName>CARM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="730" reactomeId="9009534" position="3728 2368" bounds="3666 2315 124 106" textPosition="3666 2357" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="746" reactomeId="9018504" position="1012 2015" bounds="972 1983 81 65" textPosition="973 2010"> <Properties> <displayName>EBAG9 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="747" reactomeId="9018506" position="863 1895" bounds="801 1870 124 50" textPosition="805 1884" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EBAG9 gene:ESR1:ESTG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="750" reactomeId="9018507" position="406 2002" bounds="366 1991 81 22" textPosition="383 1991"> <Properties> <displayName>EBAG9</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="752" reactomeId="17963" position="385 1993" bounds="317 1954 137 79" textPosition="341 1957" bgColor="250 240 240" lineColor="255 153 102" insets="327 1964 117 59"> <Properties> <displayName>Golgi lumen</displayName> </Properties> <Components> <Component id="750" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="755" reactomeId="9018640" position="1315 2095" bounds="1275 2084 81 22" textPosition="1291 2084"> <Properties> <displayName>KANK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="757" reactomeId="8865330" position="1816 2265" bounds="1776 2247 81 36" textPosition="1776 2261" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="758" reactomeId="8931986" position="1746 2474" bounds="1684 2449 124 50" textPosition="1687 2463" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ESR1:estrogen</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="766" reactomeId="8932004" position="1102 2541" bounds="1040 2509 124 64" textPosition="1043 2523" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ESR1:estrogen:GPAM gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="770" reactomeId="61855" position="317 2718" bounds="270 2700 95 36" textPosition="273 2707"> <Properties> <displayName>GPAM(1-828)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="771" reactomeId="17906" position="298 2694" bounds="233 2656 131 77" textPosition="236 2669" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>mitochondrial outer membrane</displayName> </Properties> <Components> <Component id="770" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="773" reactomeId="8932036" position="1864 2578" bounds="1824 2546 81 65" textPosition="1824 2573"> <Properties> <displayName>KCTD6 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="774" reactomeId="8932035" position="1762 2676" bounds="1700 2637 124 78" textPosition="1703 2665" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ESR1:estrogen:KCTD6 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="778" reactomeId="8863321" position="2032 2936" bounds="1992 2925 81 22" textPosition="2008 2925"> <Properties> <displayName>KCTD6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="780" reactomeId="5251515" position="1323 2370" bounds="1261 2345 124 51" textPosition="1285 2372"> <Properties> <displayName>AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="781" reactomeId="8932051" position="1189 2208" bounds="1127 2183 124 50" textPosition="1141 2197" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="783" reactomeId="8932085" position="1079 2445" bounds="1017 2413 124 64" textPosition="1020 2427" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:ESR1:estrogen:AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="791" reactomeId="195249" position="346 2329" bounds="313 2318 66 22" textPosition="324 2318"> <Properties> <displayName>AXIN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="796" reactomeId="8864987" position="2987 2220" bounds="2925 2195 124 51" textPosition="2950 2222"> <Properties> <displayName>TGFA Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="797" reactomeId="9008287" position="3089 2066" bounds="3027 2034 124 64" textPosition="3040 2048" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1 dimer:estrogen:TGFA gene promoter</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="799" reactomeId="8864301" position="3373 2068" bounds="3333 2057 81 22" textPosition="3348 2057"> <Properties> <displayName>CITED1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="800" reactomeId="9008249" position="3610 2028" bounds="3548 1982 124 92" textPosition="3561 2010" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CITED1:EP300:ESR1:estrogen:TGFA gene promoter</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="802" reactomeId="5689476" position="4567 2171" bounds="4520 2153 95 36" textPosition="4535 2153"> <Properties> <displayName>TGFA precursor</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="809" reactomeId="1252016" position="1327 1779" bounds="1265 1768 124 22" textPosition="1293 1768"> <Properties> <displayName>ERBB4s80</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="810" reactomeId="1254397" position="1271 1653" bounds="1209 1628 124 50" textPosition="1219 1642" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ERBB4s80:ESR1:estrogen</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="812" reactomeId="8954206" position="968 1511" bounds="913 1486 110 51" textPosition="936 1513"> <Properties> <displayName>PGR gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="813" reactomeId="8954204" position="986 1385" bounds="924 1353 124 64" textPosition="927 1381" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ERBB4s80:ESR1:estrogen:PGR gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="815" reactomeId="8954202" position="920 1711" bounds="873 1679 95 65" textPosition="877 1706"> <Properties> <displayName>CXCL12 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="816" reactomeId="8954210" position="831 1573" bounds="769 1534 124 78" textPosition="775 1562" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ERBB4s80:ESR1:estrogen:CXCL12 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="818" reactomeId="3008952" position="846 1421" bounds="820 1410 52 22" textPosition="830 1410"> <Properties> <displayName>PGR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="820" reactomeId="2980693" position="56 1632" bounds="9 1614 95 36" textPosition="16 1614"> <Properties> <displayName>CXCL12(22-93)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="839" reactomeId="1236394" position="1165 1761" bounds="1106 1739 118 44" textPosition="1121 1739"> <Properties> <displayName>Signaling by ERBB4</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="840" reactomeId="8878171" position="1867 2396" bounds="1808 2360 118 72" textPosition="1814 2367"> <Properties> <displayName>Transcriptional regulation by RUNX1</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="861" reactomeId="9023829" position="2465 2128" bounds="2403 2096 124 64" textPosition="2413 2110"> <Properties> <displayName>TFF1,TFF3 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="863" reactomeId="9023820" position="2865 2361" bounds="2803 2336 124 50" textPosition="2807 2350" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TFF1 gene:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="871" reactomeId="17957" position="4575 2120" bounds="4461 2049 228 143" textPosition="4484 2114" bgColor="250 240 240" lineColor="255 153 102" insets="4473 2097 203 53"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="802" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="887" reactomeId="9008244" position="3481 1972" bounds="3419 1940 124 64" textPosition="3420 1968" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:ERE:NCOA3:TFGA gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="891" reactomeId="9008268" position="3933 2005" bounds="3871 1973 124 64" textPosition="3872 2001" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:ERE:NCOA3:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="895" reactomeId="442496" position="3080 2163" bounds="3040 2152 81 22" textPosition="3055 2152"> <Properties> <displayName>NCOA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="896" reactomeId="9023832" position="3206 2131" bounds="3144 2099 124 64" textPosition="3157 2113" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1 dimer:estrogen:TFGA gene:NCOA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="902" reactomeId="3215140" position="3507 2502" bounds="3467 2491 81 22" textPosition="3483 2491"> <Properties> <displayName>PRMT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="903" reactomeId="9023863" position="3730 2506" bounds="3668 2453 124 106" textPosition="3667 2495" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="911" reactomeId="9023862" position="4024 2285" bounds="3962 2260 124 50" textPosition="3968 2267"> <Properties> <displayName>histone acetyltransferases</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="914" reactomeId="9023865" position="3910 2407" bounds="3848 2347 124 120" textPosition="3847 2368"> <Properties> <displayName>ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="917" reactomeId="9023866" position="4158 2393" bounds="4096 2326 124 134" textPosition="4099 2382" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="921" reactomeId="9017879" position="2910 2938" bounds="2877 2927 66 22" textPosition="2892 2927"> <Properties> <displayName>TFF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="937" reactomeId="9023880" position="3401 2132" bounds="3339 2093 124 78" textPosition="3340 2121" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:estrogen:TFGA gene:NCOA1:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="971" reactomeId="9023559" position="1464 1468" bounds="1402 1443 124 51" textPosition="1428 1470"> <Properties> <displayName>CTSD gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="998" reactomeId="9023841" position="1465 1270" bounds="1403 1252 124 36" textPosition="1411 1252" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTSD gene:ESR1:ESTG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1000" reactomeId="9023564" position="1337 1066" bounds="1304 1055 66 22" textPosition="1319 1055"> <Properties> <displayName>USF2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1001" reactomeId="9023562" position="1357 1119" bounds="1324 1108 66 22" textPosition="1339 1108"> <Properties> <displayName>USF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1002" reactomeId="1592223" position="1416 1182" bounds="1390 1171 52 22" textPosition="1401 1171"> <Properties> <displayName>SP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1003" reactomeId="9023842" position="1399 953" bounds="1314 927 170 53" textPosition="1315 930" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1034" reactomeId="9023844" position="1015 1065" bounds="960 1054 110 22" textPosition="976 1054" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTSD dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="1035" reactomeId="161320" position="1048 1056" bounds="960 1009 176 94" textPosition="1002 1021" bgColor="250 240 240" lineColor="255 153 102" insets="970 1018 150 73"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="1034" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="1048" reactomeId="9023843" position="1555 994" bounds="1515 983 81 22" textPosition="1531 983"> <Properties> <displayName>NCOAs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1054" reactomeId="212445" position="1479 1139" bounds="1446 1128 66 22" textPosition="1458 1128"> <Properties> <displayName>MED1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1067" reactomeId="9032748" position="1186 946" bounds="1131 928 110 36" textPosition="1139 928" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S118-ESR1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1068" reactomeId="198701" position="1175 822" bounds="1113 804 124 36" textPosition="1113 811"> <Properties> <displayName>p-T,Y MAPK dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1092" reactomeId="8939172" position="668 980" bounds="628 969 81 22" textPosition="644 969"> <Properties> <displayName>ESR1,2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1093" reactomeId="9024328" position="656 1043" bounds="605 1021 103 44" textPosition="612 1032"> <Properties> <displayName>27-OH-CHOL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1094" reactomeId="9038025" position="846 1000" bounds="795 981 102 39" textPosition="800 984" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>27-OH-CHOL:ESR1,2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1150" reactomeId="193545" position="3206 435" bounds="3159 424 95 22" textPosition="3180 424"> <Properties> <displayName>CREBBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1151" reactomeId="9038050" position="3359 449" bounds="3297 417 124 64" textPosition="3300 445" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GREB1:ESR1:ESTG:EP300:CREBBP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1153" reactomeId="9038123" position="1336 1437" bounds="1274 1405 124 64" textPosition="1283 1419" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HSP90:ATP:PTGES3:FKBP52:PGR:P4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1154" reactomeId="113582" position="1120 1337" bounds="1090 1322 60 30" textPosition="1104 1326" /> <org.gk.render.RenderableComplex id="1155" reactomeId="9038156" position="1031 1241" bounds="984 1223 95 36" textPosition="987 1223" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:ER:PGR:P4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1156" reactomeId="5082395" position="1147 1242" bounds="1107 1224 81 36" textPosition="1122 1224"> <Properties> <displayName>HSP90:HSP90</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1157" reactomeId="5324621" position="1264 1296" bounds="1224 1285 81 22" textPosition="1242 1285"> <Properties> <displayName>FKBP4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1161" reactomeId="113550" position="1240 1240" bounds="1225 1225 31 30" textPosition="1231 1229"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1163" reactomeId="3322363" position="1012 1173" bounds="979 1162 66 22" textPosition="993 1162"> <Properties> <displayName>TLE3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1164" reactomeId="4086031" position="960 1144" bounds="927 1133 66 22" textPosition="938 1133"> <Properties> <displayName>NRIP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1165" reactomeId="9038159" position="809 1220" bounds="747 1174 124 92" textPosition="748 1216" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1166" reactomeId="453279" position="2959 1089" bounds="2900 1053 118 72" textPosition="2900 1060"> <Properties> <displayName>Mitotic G1 phase and G1/S transition</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="1169" reactomeId="9009391" position="988 227" bounds="937 191 103 72" textPosition="939 198"> <Properties> <displayName>Extra-nuclear estrogen signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1356" reactomeId="9709546" position="653 593" bounds="591 568 124 50" textPosition="600 582" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESR2:chaperone complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1357" reactomeId="9709545" position="844 590" bounds="782 565 124 50" textPosition="783 579" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESTG:ESR2:chaperone complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1358" reactomeId="29358" position="1082 916" bounds="1052 901 60 30" textPosition="1066 905"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1388" reactomeId="9709550" position="1665 465" bounds="1633 454 64 22" textPosition="1633 454"> <Properties> <displayName>ESR:ESTG</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1390" reactomeId="113582" position="1303 500" bounds="1283 485 41 30" textPosition="1287 489" /> <org.gk.render.RenderableEntitySet id="1419" reactomeId="9709543" position="1204 465" bounds="1138 447 133 36" textPosition="1138 447"> <Properties> <displayName>ESR:ESTG:chaperone complex</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1444" reactomeId="9710004" position="1899 464" bounds="1840 453 119 22" textPosition="1840 453"> <Properties> <displayName>ESR multimer:ESTG</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1459" reactomeId="9716925" position="1042 690" bounds="998 679 89 22" textPosition="998 679" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>ESR1 agonists</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1460" reactomeId="9716887" position="1003 595" bounds="963 577 80 36" textPosition="966 577" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ESR1:ESR1 agonists</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1469" reactomeId="9716906" position="1005 791" bounds="952 780 107 22" textPosition="952 780" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>ESR1 antagonists</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1471" reactomeId="9716943" position="1149 614" bounds="1112 596 75 36" textPosition="1112 596" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ESR1:ESR1 antagonists</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1472" reactomeId="2393968" position="1350 2717" bounds="1313 2691 75 52" textPosition="1313 2718"> <Properties> <displayName>GPAM gene</displayName> </Properties> </org.gk.render.RenderableGene> </Nodes> <Edges> <org.gk.render.RenderableReaction id="48" reactomeId="8939205" points="829 110, 840 302, 852 447" position="840 302" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="49" /> </Inputs> <Outputs> <Output id="50" /> </Outputs> <Properties> <displayName>ESTG translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="8939203" points="1277 464, 1312 464, 1385 464" position="1312 464" lineWidth="1.0"> <Inputs> <Input id="1419" /> </Inputs> <Outputs> <Output id="60" stoichiometry="2" points="1529 547" /> <Output id="63" stoichiometry="2" points="1451 563" /> <Output id="55" stoichiometry="2" points="1320 550" /> <Output id="1388" points="1627 464" /> <Output id="56" stoichiometry="2" points="1370 577" /> <Output id="1390" points="1327 491" /> </Outputs> <Catalysts> <Catalyst id="1419" points="1246 441, 1311 420" /> </Catalysts> <Properties> <displayName>HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="8939201" points="1703 464, 1791 464, 1834 464" position="1791 464" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1388" stoichiometry="2" /> </Inputs> <Outputs> <Output id="1444" /> </Outputs> <Properties> <displayName>ESR dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="9009065" points="2361 1307, 2380 1307, 2397 1304" position="2380 1307" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="66" points="2312 1393" /> <Input id="67" points="2330 1307" /> <Input id="68" points="2417 1393" /> </Inputs> <Outputs> <Output id="69" points="2421 1225" /> <Output id="70" points="2483 1304" /> <Output id="71" points="2447 1260" /> </Outputs> <Properties> <displayName>FOXA1 and GATA3 bind to CCND1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="9009371" points="2647 1300, 2649 1300, 2824 1299" position="2649 1300" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="105" points="2733 1263" /> <Input id="103" points="2606 1202" /> <Input id="151" points="2704 1425" /> <Input id="104" points="2747 1182" /> <Input id="70" points="2613 1301" /> </Inputs> <Outputs> <Output id="106" /> </Outputs> <Properties> <displayName>Binding of AP1 transcriptional activator complexes to CCND1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="9009378" points="2974 1131, 3018 1291, 3048 1178" position="3018 1291" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="147" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Activators> <Activator id="106" points="2959 1294" /> <Activator id="266" points="3035 1353" /> </Activators> <Properties> <displayName>Estrogen-responsive CCND1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="9011975" points="1969 1396, 2038 1328, 2105 1199" position="2038 1328" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="153" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Activators> <Activator id="155" points="1992 1209" /> <Activator id="253" points="2144 1418" /> <Activator id="267" points="2193 1216" /> </Activators> <Properties> <displayName>Estrogen-responsive MYC gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="156" reactomeId="9011997" points="1974 1305, 1976 1305, 1977 1209" position="1976 1305" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="165" points="1905 1311" /> <Input id="157" points="1877 1268" /> <Input id="153" points="1969 1396" /> <Input id="158" points="1651 1693, 1808 1495" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> <Properties> <displayName>ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="237" reactomeId="9011984" points="2013 1692, 2031 1691, 2053 1691" position="2031 1691" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="238" points="1997 1692" /> <Input id="239" points="1988 1870" /> </Inputs> <Outputs> <Output id="240" /> </Outputs> <Properties> <displayName>KDM1A is recruited to MYC and BCL2 genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="241" reactomeId="9011985" points="2183 1694, 2235 1696, 2273 1697" position="2235 1696" lineWidth="1.0"> <Inputs> <Input id="240" /> </Inputs> <Outputs> <Output id="239" points="2009 1870, 2227 1764" /> <Output id="242" points="2387 1691" /> </Outputs> <Catalysts> <Catalyst id="240" points="2163 1629, 2175 1617" /> </Catalysts> <Properties> <displayName>KDM1A demethylates H3 on MYC and BCL genes in response to estrogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="9011983" points="1748 1696, 1804 1690, 1838 1690" position="1804 1690" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="245" stoichiometry="2" points="1744 1666" /> <Input id="246" points="1783 1740" /> <Input id="158" points="1708 1700" /> </Inputs> <Outputs> <Output id="238" points="1867 1690" /> <Output id="247" stoichiometry="2" points="1865 1632" /> </Outputs> <Properties> <displayName>Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="248" reactomeId="9011941" points="3122 1671, 3150 1674, 3151 1547" position="3150 1674" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="249" /> </Inputs> <Outputs> <Output id="250" /> </Outputs> <Activators> <Activator id="252" points="3079 1620" /> </Activators> <Properties> <displayName>Estrogen-responsive BCL2 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="9011952" points="1828 1097, 1876 1099, 1966 1077" position="1876 1099" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="269" points="1871 980" /> <Input id="270" points="1805 1086" /> <Input id="158" points="1646 1693" /> </Inputs> <Outputs> <Output id="271" /> </Outputs> <Properties> <displayName>ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="272" reactomeId="9011949" points="2096 1059, 2175 1056, 2237 1050" position="2175 1056" lineWidth="1.0"> <Inputs> <Input id="271" /> </Inputs> <Outputs> <Output id="269" points="1919 962, 2133 942" /> <Output id="273" points="2333 1070" /> </Outputs> <Catalysts> <Catalyst id="271" points="2096 1030, 2163 994" /> </Catalysts> <Properties> <displayName>KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="274" reactomeId="9011971" points="3388 985, 3439 1006, 3525 1000" position="3439 1006" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="275" /> </Inputs> <Outputs> <Output id="276" /> </Outputs> <Activators> <Activator id="447" points="3436 985" /> </Activators> <Properties> <displayName>Estrogen-responsive MYB gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="374" reactomeId="9012000" points="3041 791, 3044 758, 3042 709" position="3044 758" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="375" points="2941 742" /> <Input id="376" points="2941 773" /> <Input id="377" points="3058 864" /> <Input id="378" points="2799 798" /> </Inputs> <Outputs> <Output id="373" /> </Outputs> <Properties> <displayName>NR5A2, ZNF217 and NCOA3 bind GREB1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="405" reactomeId="9011966" points="2072 806, 2205 875, 1914 952" position="2205 875" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="301" /> </Inputs> <Outputs> <Output id="269" /> </Outputs> <Activators> <Activator id="404" points="2402 899" /> </Activators> <Properties> <displayName>Estrogen-responsive KDM4B gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="418" reactomeId="9012205" points="2164 400, 2153 272, 2143 223" position="2153 272" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="419" /> </Inputs> <Outputs> <Output id="420" /> </Outputs> <Activators> <Activator id="50" points="894 453, 1502 271" /> </Activators> <Properties> <displayName>Estrogen-responsive CHD1 gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="422" reactomeId="9011950" points="2893 442, 2919 417, 2891 293" position="2919 417" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="423" /> </Inputs> <Outputs> <Output id="424" /> </Outputs> <Activators> <Activator id="373" points="3009 583" /> </Activators> <Properties> <displayName>Estrogen-responsive GREB1 gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="427" reactomeId="9012203" points="2269 242, 2286 251, 2328 285" position="2286 251" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="403" points="2298 223" /> <Input id="420" points="2213 223" /> </Inputs> <Outputs> <Output id="428" /> </Outputs> <Properties> <displayName>miR-26A and B bind to the 3'UTR of the CHD11 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="429" reactomeId="9011958" points="2982 224, 3026 219, 3083 219" position="3026 219" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="424" points="2938 251" /> <Input id="403" points="2379 207" /> </Inputs> <Outputs> <Output id="401" /> </Outputs> <Properties> <displayName>miR-26A and B bind to the 3'UTR of the GREB1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="430" reactomeId="9012186" points="2154 223, 2241 336, 2266 442" position="2241 336" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="420" /> </Inputs> <Outputs> <Output id="431" /> </Outputs> <Inhibitors> <Inhibitor id="428" points="2284 323" /> </Inhibitors> <Properties> <displayName>CHD1 translation is negatively regulated by miR-26A and B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="432" reactomeId="9012209" points="2732 427, 2671 366, 2660 266" position="2671 366" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="433" /> </Inputs> <Outputs> <Output id="434" /> </Outputs> <Activators> <Activator id="50" points="894 458, 1227 398, 1863 402, 2321 525, 2580 529" /> </Activators> <Properties> <displayName>Estrogen-responsive KPNA2 gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="435" reactomeId="9012208" points="2486 232, 2501 253, 2505 270" position="2501 253" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="403" points="2379 215" /> <Input id="434" points="2599 240" /> </Inputs> <Outputs> <Output id="436" /> </Outputs> <Properties> <displayName>miR-26A and B bind to the 3'UTR of the KPNA2 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="437" reactomeId="9012196" points="2639 266, 2544 408, 2539 447" position="2544 408" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="434" /> </Inputs> <Outputs> <Output id="438" /> </Outputs> <Inhibitors> <Inhibitor id="436" points="2518 326" /> </Inhibitors> <Properties> <displayName>KPNA2 translation is negatively regulated by miR-26A and B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="440" reactomeId="9011961" points="2946 295, 3037 336, 3078 412" position="3037 336" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="424" /> </Inputs> <Outputs> <Output id="441" /> </Outputs> <Inhibitors> <Inhibitor id="401" points="3118 248" /> </Inhibitors> <Properties> <displayName>GREB1 translation is negatively regulated by miR-26A and B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="448" reactomeId="9012315" points="3551 774, 3599 782, 3635 789" position="3599 782" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="453" points="3535 667" /> <Input id="450" points="3519 787" /> </Inputs> <Outputs> <Output id="451" /> </Outputs> <Properties> <displayName>ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="454" reactomeId="9012319" points="3651 860, 3625 883, 3603 889" position="3625 883" lineWidth="1.0"> <Inputs> <Input id="455" stoichiometry="52" points="3728 912" /> <Input id="451" points="3638 860" /> </Inputs> <Outputs> <Output id="456" stoichiometry="52" points="3615 933" /> <Output id="447" points="3494 910" /> </Outputs> <Catalysts> <Catalyst id="451" points="3635 828, 3586 852" /> </Catalysts> <Properties> <displayName>p-TEFb phosphorylates serine 2 in RNA polymerase II CTD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="634" reactomeId="9018325" points="1472 1961, 1355 1939, 1259 2015" position="1355 1939" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="158" points="1635 1721" /> <Input id="635" points="1497 2017" /> </Inputs> <Outputs> <Output id="636" /> </Outputs> <Properties> <displayName>ESR1:ESTG binds CXXC5 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="639" reactomeId="9018334" points="1497 2017, 1357 2021, 1363 2061, 1345 2149" position="1363 2061" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="635" /> </Inputs> <Outputs> <Output id="640" /> </Outputs> <Activators> <Activator id="636" points="1294 2051" /> <Activator id="755" points="1330 2081" /> </Activators> <Properties> <displayName>Estrogen-responsive CXXC5 gene expresion</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="671" reactomeId="9018494" points="2328 2135, 2362 2135, 2397 2132" position="2362 2135" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" points="2423 1421" /> <Input id="66" points="2306 1421" /> <Input id="672" points="2291 2136" /> </Inputs> <Outputs> <Output id="861" /> </Outputs> <Properties> <displayName>FOXA1 and GATA3 bind TFF genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="688" reactomeId="9018499" points="2716 2141, 2735 2141, 2809 2135" position="2735 2141" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="158" points="1649 1721, 1810 1980, 2621 2038" /> <Input id="689" points="2682 2140" /> <Input id="151" points="2709 1453" /> </Inputs> <Outputs> <Output id="690" /> </Outputs> <Properties> <displayName>ESR1:ESTG and EP300 are recruited to TFF3 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="696" reactomeId="9018497" points="2578 2260, 2576 2226, 2657 2225, 2732 2224, 2759 2940" position="2657 2225" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="697" /> </Inputs> <Outputs> <Output id="699" /> </Outputs> <Activators> <Activator id="690" points="2809 2157" /> </Activators> <Properties> <displayName>Estrogen-responsive TFF3 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="698" points="2578 2260, 2275 2163" position="2426 2211" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="697" /> </Inputs> <Outputs> <Output id="672" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="713" reactomeId="9009541" points="2990 2362, 3025 2363, 3056 2363" position="3025 2363" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="863" points="2930 2361" /> <Input id="714" points="2889 2295" /> </Inputs> <Outputs> <Output id="717" /> </Outputs> <Properties> <displayName>ESR1 binds to TFF1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="716" points="2927 2466, 2261 2163" position="2594 2314" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="715" /> </Inputs> <Outputs> <Output id="672" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="720" reactomeId="9009536" points="3228 2366, 3241 2365, 3263 2362" position="3241 2365" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="721" points="3208 2316" /> <Input id="717" points="3186 2365" /> </Inputs> <Outputs> <Output id="722" /> </Outputs> <Properties> <displayName>DDX5 binds ESR1:estrogen:TFF1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="723" reactomeId="9009533" points="3410 2365, 3428 2363, 3454 2362" position="3428 2363" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="724" points="3438 2429" /> <Input id="722" points="3393 2362" /> <Input id="725" points="3383 2439" /> </Inputs> <Outputs> <Output id="726" /> </Outputs> <Properties> <displayName>TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="727" reactomeId="9011981" points="2540 1685, 2566 1684, 2728 1685" position="2566 1684" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="242" points="2517 1685" /> <Input id="151" points="2701 1453" /> </Inputs> <Outputs> <Output id="255" /> </Outputs> <Properties> <displayName>EP300 is recruited to MYC and BCL2 genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="728" reactomeId="9009526" points="3610 2367, 3631 2367, 3663 2367" position="3631 2367" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="726" points="3584 2365" /> <Input id="729" points="3575 2290" /> </Inputs> <Outputs> <Output id="730" /> </Outputs> <Properties> <displayName>CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="745" reactomeId="9018503" points="1162 1887, 928 1893" position="1162 1887" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="158" points="1613 1721" /> <Input id="746" points="1062 1985" /> </Inputs> <Outputs> <Output id="747" /> </Outputs> <Properties> <displayName>ESR1:ESTG bind the EBAG9 5' region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="749" reactomeId="9018505" points="1062 1985, 818 2002, 450 2002" position="818 2002" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="746" /> </Inputs> <Outputs> <Output id="750" /> </Outputs> <Activators> <Activator id="747" points="852 1923" /> </Activators> <Properties> <displayName>Estrogen-responsive EBAG9 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="756" reactomeId="8931981" points="1735 2315, 1736 2351, 1743 2446" position="1736 2351" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="757" points="1786 2286" /> <Input id="158" points="1644 1721" /> </Inputs> <Outputs> <Output id="758" /> </Outputs> <Properties> <displayName>RUNX1 binds ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="764" reactomeId="8932021" points="1382 2604, 1316 2565, 1167 2547" position="1316 2565" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="758" points="1681 2496" /> <Input id="1472" points="1397 2693" /> </Inputs> <Outputs> <Output id="766" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the GPAM gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="769" reactomeId="8932020" points="1397 2693, 1059 2717, 368 2717" position="1059 2717" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1472" /> </Inputs> <Outputs> <Output id="770" /> </Outputs> <Activators> <Activator id="766" points="1094 2576" /> </Activators> <Properties> <displayName>GPAM gene expression is stimulated by RUNX1 and ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="772" reactomeId="8932037" points="1750 2528, 1754 2559, 1759 2634" position="1754 2559" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="758" points="1747 2502" /> <Input id="773" points="1914 2548" /> </Inputs> <Outputs> <Output id="774" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the KCTD6 gene enhancer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="777" reactomeId="8932033" points="1914 2548, 1979 2565, 2001 2712, 2030 2922" position="2001 2712" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="773" /> </Inputs> <Outputs> <Output id="778" /> </Outputs> <Activators> <Activator id="774" points="1827 2685" /> </Activators> <Properties> <displayName>KCTD6 gene expression is stimulated by RUNX1 and ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="779" reactomeId="8932070" points="1489 2301, 1433 2287, 1254 2228" position="1433 2287" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="780" points="1394 2347" /> <Input id="158" points="1640 1721" /> </Inputs> <Outputs> <Output id="781" /> </Outputs> <Properties> <displayName>ESR1 binds the AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="782" reactomeId="8932084" points="1349 2487, 1267 2483, 1144 2457" position="1267 2483" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="758" points="1681 2476" /> <Input id="780" points="1394 2347, 1419 2419" /> </Inputs> <Outputs> <Output id="783" /> </Outputs> <Properties> <displayName>RUNX1 and ESR1 bind the AXIN1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="790" reactomeId="8932076" points="1394 2347, 1063 2328, 382 2328" position="1063 2328" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="780" /> </Inputs> <Outputs> <Output id="791" /> </Outputs> <Inhibitors> <Inhibitor id="781" points="1162 2236" /> </Inhibitors> <Activators> <Activator id="783" points="1074 2410" /> </Activators> <Properties> <displayName>AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="795" reactomeId="9008267" points="2999 2176, 3014 2129, 3050 2101" position="3014 2129" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="796" points="3058 2197" /> <Input id="714" points="2888 2253" /> </Inputs> <Outputs> <Output id="797" /> </Outputs> <Properties> <displayName>ESR1 binds to TGFA gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="798" reactomeId="9008271" points="3444 2025, 3486 2029, 3545 2028" position="3486 2029" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="151" points="2718 1453, 2943 1697, 3060 1918" /> <Input id="799" points="3391 2054" /> <Input id="797" points="3154 2058" /> </Inputs> <Outputs> <Output id="800" /> </Outputs> <Properties> <displayName>CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="803" reactomeId="9008315" points="3058 2197, 3432 2224, 3540 2179, 4517 2171" position="3540 2179" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="796" /> </Inputs> <Outputs> <Output id="802" /> </Outputs> <Activators> <Activator id="800" points="3588 2077" /> <Activator id="891" points="3868 2032" /> <Activator id="937" points="3466 2152" /> </Activators> <Properties> <displayName>TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="808" reactomeId="1254386" points="1368 1744, 1337 1709, 1300 1681" position="1337 1709" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="809" points="1339 1762" /> <Input id="158" points="1578 1715" /> </Inputs> <Outputs> <Output id="810" /> </Outputs> <Properties> <displayName>ERBB4s80 forms a complex with estrogen receptor ESR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="811" reactomeId="8954208" points="1166 1576, 1145 1521, 1023 1420" position="1145 1521" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="812" points="1032 1488" /> <Input id="810" points="1236 1625" /> </Inputs> <Outputs> <Output id="813" /> </Outputs> <Properties> <displayName>ERBB4s80:ESR1 binds PGR gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="814" reactomeId="8954207" points="1139 1628, 1042 1595, 896 1579" position="1042 1595" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="810" points="1206 1641" /> <Input id="815" points="977 1681" /> </Inputs> <Outputs> <Output id="816" /> </Outputs> <Properties> <displayName>ERBB4s80:ESR1 binds CXCL12 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="817" reactomeId="1254392" points="1032 1488, 976 1468, 875 1430" position="976 1468" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="812" /> </Inputs> <Outputs> <Output id="818" /> </Outputs> <Activators> <Activator id="813" points="982 1420" /> </Activators> <Properties> <displayName>PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="819" reactomeId="8954199" points="977 1681, 783 1633, 107 1632" position="783 1633" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="815" /> </Inputs> <Outputs> <Output id="820" /> </Outputs> <Activators> <Activator id="816" points="799 1615" /> </Activators> <Properties> <displayName>CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="844" interactionType="Activate" points="1227 1767, 1259 1771" position="1243 1769" lineWidth="2.0"> <Inputs> <Input id="839" /> </Inputs> <Outputs> <Output id="809" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="846" interactionType="Activate" points="1852 2357, 1823 2286" position="1837 2321" lineWidth="2.0"> <Inputs> <Input id="840" /> </Inputs> <Outputs> <Output id="757" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.EntitySetAndMemberLink id="862" points="2552 2133, 2533 2131" position="2542 2132" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="689" /> </Inputs> <Outputs> <Output id="861" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="864" points="2820 2333, 2520 2166" position="2670 2249" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="863" /> </Inputs> <Outputs> <Output id="861" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="886" reactomeId="9008258" points="3332 1978, 3388 1972, 3416 1972" position="3388 1972" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="377" stoichiometry="2" points="3064 892, 3142 1126, 3419 1424" /> <Input id="797" points="3154 2043" /> </Inputs> <Outputs> <Output id="887" /> </Outputs> <Properties> <displayName>NCOA3 binds ESR1:estrogen:TFGA gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="890" reactomeId="9008285" points="3665 1950, 3738 1956, 3868 1989" position="3738 1956" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="151" points="2720 1453, 2964 1684, 3071 1890" /> <Input id="887" points="3546 1964" /> </Inputs> <Outputs> <Output id="891" /> </Outputs> <Properties> <displayName>NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="894" reactomeId="9008270" points="3098 2126, 3117 2126, 3141 2127" position="3117 2126" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="895" points="3085 2149" /> <Input id="797" points="3093 2101" /> </Inputs> <Outputs> <Output id="896" /> </Outputs> <Properties> <displayName>NCOA1 binds ESR1:estrogen:TGFA gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="901" reactomeId="9023861" points="3572 2461, 3572 2462, 3665 2488" position="3572 2462" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="726" points="3543 2411" /> <Input id="902" points="3524 2488" /> </Inputs> <Outputs> <Output id="903" /> </Outputs> <Properties> <displayName>PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="910" reactomeId="9023860" points="4025 2396, 4057 2394, 4093 2393" position="4057 2394" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="911" points="4024 2316" /> <Input id="914" points="3978 2401" /> </Inputs> <Outputs> <Output id="917" /> </Outputs> <Properties> <displayName>Histone acetyltransferases are recruited to the TFF1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="912" points="3395 2082, 3472 2117, 3956 2266" position="3472 2117" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="799" /> </Inputs> <Outputs> <Output id="911" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="913" points="2753 1442, 3994 1561, 4022 2254" position="3994 1561" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="151" /> </Inputs> <Outputs> <Output id="911" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="915" points="3795 2469, 3842 2440" position="3818 2454" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="903" /> </Inputs> <Outputs> <Output id="914" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="916" points="3793 2381, 3842 2393" position="3817 2387" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="730" /> </Inputs> <Outputs> <Output id="914" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="920" reactomeId="9023859" points="2927 2466, 2904 2701, 2909 2924" position="2904 2701" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="715" /> </Inputs> <Outputs> <Output id="921" /> </Outputs> <Activators> <Activator id="917" points="4093 2456, 3957 2600" /> </Activators> <Properties> <displayName>Estrogen-responsive TFF1 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="936" reactomeId="9023884" points="3301 2122, 3319 2122, 3336 2124" position="3319 2122" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="896" points="3271 2125" /> <Input id="151" points="2717 1453, 2915 1702, 3041 1931" /> </Inputs> <Outputs> <Output id="937" /> </Outputs> <Properties> <displayName>NCOA1 recruits EP300 to TGFA promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="970" reactomeId="9023846" points="1535 1445, 1181 1065, 1073 1065" position="1181 1065" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="971" /> </Inputs> <Outputs> <Output id="1034" /> </Outputs> <Activators> <Activator id="1003" points="1347 983" /> </Activators> <Properties> <displayName>Estrogen-responsive CTSD expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="997" reactomeId="9023845" points="1538 1362, 1536 1333, 1485 1291" position="1536 1333" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="971" points="1535 1445" /> <Input id="158" stoichiometry="2" points="1639 1693" /> </Inputs> <Outputs> <Output id="998" /> </Outputs> <Properties> <displayName>ESR1:ESTG binds to proximal and distal regions of the CTSD promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="999" reactomeId="9023840" points="1426 1043, 1427 1044, 1407 983" position="1427 1044" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1000" points="1373 1057" /> <Input id="1001" points="1366 1105" /> <Input id="998" points="1461 1249" /> <Input id="1048" points="1526 1011" /> <Input id="151" points="2691 1453, 2527 1553, 1639 1498, 1636 1162" /> <Input id="1054" points="1472 1125" /> <Input id="1002" points="1416 1168" /> </Inputs> <Outputs> <Output id="1003" /> </Outputs> <Properties> <displayName>HATs and coactivators are recruited to the CTSD gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1049" points="3068 2149, 2497 1604, 1638 1571, 1556 1011" position="2067 1587" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="895" /> </Inputs> <Outputs> <Output id="1048" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1050" points="3018 874, 1695 765, 1561 977" position="1695 765" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="377" /> </Inputs> <Outputs> <Output id="1048" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="1051" points="1602 995, 4076 1080, 4025 2254" position="4076 1080" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1048" /> </Inputs> <Outputs> <Output id="911" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="1072" reactomeId="8939204" points="949 465, 950 464, 1016 464" position="950 464" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="52" points="910 677" /> <Input id="50" points="894 465" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Properties> <displayName>ESTG binds ESR1:chaperone complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1073" reactomeId="9032751" points="1120 877, 1174 877, 1246 877" position="1174 877" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="52" points="905 733, 905 876" /> <Input id="1358" points="1096 898" /> </Inputs> <Outputs> <Output id="63" points="1454 597, 1354 877" /> <Output id="55" points="1306 586" /> <Output id="60" points="1549 599, 1363 889" /> <Output id="1067" points="1201 925" /> <Output id="56" points="1364 606" /> <Output id="1390" points="1300 518" /> </Outputs> <Catalysts> <Catalyst id="1068" points="1174 846" /> </Catalysts> <Properties> <displayName>Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1091" reactomeId="9038029" points="749 998, 748 999, 792 999" position="748 999" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1092" points="715 989" /> <Input id="1093" points="701 1018" /> </Inputs> <Outputs> <Output id="1094" /> </Outputs> <Properties> <displayName>27-hydroxysterol binds ESR1, ESR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1149" reactomeId="9038052" points="3235 557, 3270 532, 3324 484" position="3270 532" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="151" points="2753 1439, 3138 1447" /> <Input id="441" points="3096 440" /> <Input id="158" points="1643 1693, 1688 620" /> <Input id="1150" points="3208 449" /> </Inputs> <Outputs> <Output id="1151" /> </Outputs> <Properties> <displayName>GREB1 binds ESR1:ESTG and co-activators</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1152" reactomeId="9038161" points="1228 1406, 1205 1377, 1199 1333" position="1205 1377" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="158" points="1621 1693, 1350 1556" /> <Input id="1153" points="1271 1419" /> </Inputs> <Outputs> <Output id="1154" points="1153 1335" /> <Output id="56" stoichiometry="2" points="1366 606" /> <Output id="1155" points="1063 1262" /> <Output id="1156" points="1157 1266" /> <Output id="1157" points="1244 1310" /> <Output id="1161" points="1233 1258" /> </Outputs> <Catalysts> <Catalyst id="1153" points="1304 1402, 1250 1351" /> </Catalysts> <Properties> <displayName>Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1162" reactomeId="9038163" points="944 1215, 909 1219, 874 1219" position="909 1219" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1163" points="994 1187" /> <Input id="66" points="2302 1421, 2261 1569, 1203 1525" /> <Input id="1155" points="981 1226" /> <Input id="68" points="2424 1421, 2411 1581, 1185 1547" /> <Input id="1164" points="957 1158" /> </Inputs> <Outputs> <Output id="1165" /> </Outputs> <Properties> <displayName>ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1168" interactionType="Activate" points="3036 1150, 3004 1128" position="3020 1139" lineWidth="2.0"> <Inputs> <Input id="148" /> </Inputs> <Outputs> <Output id="1166" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1355" reactomeId="9709547" points="745 590, 746 590, 779 590" position="746 590" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1356" points="718 590" /> <Input id="50" points="840 483" /> </Inputs> <Outputs> <Output id="1357" /> </Outputs> <Properties> <displayName>ESTG binds ESR2:chaperone complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1420" points="909 569, 1152 489" position="1030 529" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1357" /> </Inputs> <Outputs> <Output id="1419" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1421" points="1110 464, 1132 464" position="1121 464" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="1419" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1445" points="1645 1693, 1896 481" position="1770 1087" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="158" /> </Inputs> <Outputs> <Output id="1444" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1458" reactomeId="9716947" points="1001 654, 1002 654, 1002 616" position="1002 654" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1459" points="1029 673" /> <Input id="52" points="952 677" /> </Inputs> <Outputs> <Output id="1460" /> </Outputs> <Properties> <displayName>ESR1 binds ESR1 agonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1468" reactomeId="9716913" points="1004 745, 1005 745, 1148 704, 1148 635" position="1005 745" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1469" points="1004 774" /> <Input id="52" points="967 733" /> </Inputs> <Outputs> <Output id="1471" /> </Outputs> <Properties> <displayName>ESR1 binds ESR1 antagonists</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Estrogen responsive signaling and Estrogen-responsive signaling in cancer (8939215)
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