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Details on Person Vanin (VNN1) is a membrane pantetheine hydrolase or pantethe...
| Class:Id | Summation:8939006 |
|---|---|
| _displayName | Vanin (VNN1) is a membrane pantetheine hydrolase or pantethe... |
| _timestamp | 2023-06-14 18:44:08 |
| created | [InstanceEdit:8938999] Jupe, Steve, 2016-09-15 |
| literatureReference | [LiteratureReference:8939036] Is pantetheinase the actual identity of mouse and human vanin-1 proteins? [LiteratureReference:8938998] Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes [LiteratureReference:8939011] Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases [LiteratureReference:8939033] The structure of vanin 1: a key enzyme linking metabolic disease and inflammation |
| modified | [InstanceEdit:8940992] Jupe, Steve, 2016-09-29 [InstanceEdit:8941893] Jupe, Steve, 2016-10-07 [InstanceEdit:9837407] D'Eustachio, Peter, 2023-06-14 |
| text | Vanin (VNN1) is a membrane pantetheine hydrolase or pantetheinase (EC 3.56.1.-) (Maras et al. 1999, Martin et al. 2001), part of a cluster of three human orthologous genes (VNN1, VNN2, VNN3) on Chr. 6q22-24 (Kaskow et al. 2012, Boersma et al. 2014). VNN3 is a pseudogene in humans. Vanins catalyse the hydrolysis of pantetheine to pantothenic acid (PanK, vitamin B5) and cysteamine (2AET), a powerful anti-oxidant. PanK is the initial substrate for the synthesis of Coenzyme A (CoA-SH). Mouse Vnn1 has been shown to be GPI-anchored to the outer face of the plasma membrane. Sequence motifs conserved with human VNN1 and VNN2 supports the inference that the human proteins are similarly anchored (Aurand-Lions et al. 1996; Naquet et al. 2020), so the enzymes are annotated as acting on extracellular panthetheine to generate extracellular PanK and 2AET. |
| (summation) | [Reaction:8938300] Vanin hydrolyses pantetheine to PanK, 2AET [Homo sapiens] |
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