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Details on Person Vanin hydrolyses pantetheine to PanK, 2AET

Class:Id	Reaction:8938300
_displayName	Vanin hydrolyses pantetheine to PanK, 2AET
_doRelease	TRUE
_timestamp	2023-06-14 18:48:11
authored	[InstanceEdit:8938307] Jupe, Steve, 2016-09-09
catalystActivity	[CatalystActivity:8939020] pantetheine hydrolase activity of VNN1,VNN2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8938307] Jupe, Steve, 2016-09-09
edited	[InstanceEdit:8942174] Jupe, Steve, 2016-10-10
input	[SimpleEntity:8939157] Pantetheine [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8939036] Is pantetheinase the actual identity of mouse and human vanin-1 proteins? [LiteratureReference:9837329] Regulation of coenzyme A levels by degradation: the 'Ins and Outs' [LiteratureReference:9837415] Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing
modified	[InstanceEdit:8938999] Jupe, Steve, 2016-09-15 [InstanceEdit:8940992] Jupe, Steve, 2016-09-29 [InstanceEdit:8941893] Jupe, Steve, 2016-10-07 [InstanceEdit:8942181] Jupe, Steve, 2016-10-10 [InstanceEdit:8948755] Jupe, Steve, 2016-11-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9837407] D'Eustachio, Peter, 2023-06-14 [InstanceEdit:9837433] D'Eustachio, Peter, 2023-06-14
name	Vanin hydrolyses pantetheine to PanK, 2AET (R)-pantetheine + H2O => (R)-pantothenate + cysteamine
output	[SimpleEntity:9837424] 2AET [extracellular region] [SimpleEntity:199192] PanK [extracellular region]
precedingEvent	[Reaction:199203] PANK1/3 phosphorylate PanK [Homo sapiens] [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol [Homo sapiens]
releaseDate	2016-12-12
reviewed	[InstanceEdit:8943675] D'Eustachio, Peter, 2016-10-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8938319] R-HSA-8938300.3
summation	[Summation:8939006] Vanin (VNN1) is a membrane pantetheine hydrolase or pantethe...
(hasEvent)	[Pathway:199220] Vitamin B5 (pantothenate) metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842298] Update Tracker - [Reaction:8938300] Vanin hydrolyses pantetheine to PanK, 2AET - v86:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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