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Details on Person PF4 gene transcription is stimulated by RUNX1:CBFB

Class:Id	BlackBoxEvent:8938174
_displayName	PF4 gene transcription is stimulated by RUNX1:CBFB
_doRelease	TRUE
_timestamp	2017-05-09 14:03:54
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm [Compartment:114506] platelet alpha granule lumen
created	[InstanceEdit:8938180] Orlic-Milacic, Marija, 2016-09-08
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:8938181] PF4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8938179] Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
modified	[InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:8955747] Orlic-Milacic, Marija, 2017-01-13 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PF4 gene transcription is stimulated by RUNX1:CBFB
output	[DefinedSet:8938182] PF4 [platelet alpha granule lumen] [Homo sapiens]
precedingEvent	[Reaction:8938176] RUNX1:CBFB binds the PF4 gene promoter [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8938184] Positive gene expression regulation by 'RUNX1:CBFB:PF4 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642934] Positive gene expression regulation by 'RUNX1:CBFB:PF4 gene [nucleoplasm]' Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8938189] R-HSA-8938174.4
summation	[Summation:8938177] Binding of the RUNX1:CBFB complex to the promoter of the PF4...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
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No pathways have been reviewed or authored by PF4 gene transcription is stimulated by RUNX1:CBFB (8938174)