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Details on Person Binding of the RUNX1:CBFB complex to the NR4A3 gene promoter...
| Class:Id | Summation:8938033 |
|---|---|
| _displayName | Binding of the RUNX1:CBFB complex to the NR4A3 gene promoter... |
| _timestamp | 2017-01-24 20:51:07 |
| created | [InstanceEdit:8938036] Orlic-Milacic, Marija, 2016-09-08 |
| modified | [InstanceEdit:8938040] Orlic-Milacic, Marija, 2016-09-08 [InstanceEdit:8939633] Orlic-Milacic, Marija, 2016-09-20 [InstanceEdit:8957310] Orlic-Milacic, Marija, 2017-01-24 |
| text | Binding of the RUNX1:CBFB complex to the NR4A3 gene promoter stimulates NR4A3 gene transcription, leading to reduction in the clonogenic potential of hematopoietic progenitors. RUNX1 mutants associated with familial platelet disorders (FPD) and acute myeloid leukemia (AML) are unable to transactivate the NR4A3 gene (Bluteau et al. 2011). |
| (summation) | [BlackBoxEvent:8938034] NR4A3 gene expression is stimulated by RUNX1:CBFB [Homo sapiens] |
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No pathways have been reviewed or authored by Binding of the RUNX1:CBFB complex to the NR4A3 gene promoter... (8938033)
