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Details on Person RUNX1:CBFB binds the NR4A3 gene promoter

Class:Id	Reaction:8938022
_displayName	RUNX1:CBFB binds the NR4A3 gene promoter
_doRelease	TRUE
_timestamp	2017-05-09 14:04:03
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8938027] Orlic-Milacic, Marija, 2016-09-08
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[Complex:8865330] RUNX1:CBFB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8938007] NR4A3 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8938017] Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
modified	[InstanceEdit:8955747] Orlic-Milacic, Marija, 2017-01-13 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1:CBFB binds the NR4A3 gene promoter
output	[Complex:8938010] RUNX1:CBFB:NR4A3 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8865320] CBFB binds RUNX1 [Homo sapiens] [BlackBoxEvent:8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8938031] R-HSA-8938022.2
summation	[Summation:8938012] The RUNX1:CBFB complex bind the RUNX1 site in the promoter o...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8938034] NR4A3 gene expression is stimulated by RUNX1:CBFB [Homo sapiens]
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No pathways have been reviewed or authored by RUNX1:CBFB binds the NR4A3 gene promoter (8938022)