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Details on Person RUNX3 translocates to the nucleus

Class:Id	Reaction:8937814
_displayName	RUNX3 translocates to the nucleus
_doRelease	TRUE
_timestamp	2017-01-31 16:55:47
authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:8937812] Orlic-Milacic, Marija, 2016-09-06
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
input	[EntityWithAccessionedSequence:8937797] RUNX3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8937789] Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm [LiteratureReference:8952360] RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization
modified	[InstanceEdit:8952370] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8959882] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:8959887] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:8959889] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX3 translocates to the nucleus
output	[EntityWithAccessionedSequence:8865393] RUNX3 [nucleoplasm] [Homo sapiens]
regulatedBy	[NegativeRegulation:8937813] Negative regulation by 'MyrG-p-Y419-SRC [plasma membrane]' [PositiveRegulation:8952365] Positive regulation by 'Dimeric TGFB1 [extracellular region]'
regulationReference	[RegulationReference:9641196] Negative regulation by 'MyrG-p-Y419-SRC [plasma membrane]' Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm [RegulationReference:9641387] Positive regulation by 'Dimeric TGFB1 [extracellular region]' RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization
releaseDate	2017-03-27
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8937816] R-HSA-8937814.4
summation	[Summation:8937815] Translocation of RUNX3 from the cytosol to the nucleus is st...
(hasEvent)	[Pathway:8941858] Regulation of RUNX3 expression and activity [Homo sapiens]
(precedingEvent)	[Reaction:8865454] CBFB binds RUNX3 [Homo sapiens] [BlackBoxEvent:8878117] RUNX3 binds ZFHX3 [Homo sapiens] [Reaction:8878143] RUNX3 binds SMAD3 and SMAD4 [Homo sapiens] [Reaction:8878193] RUNX3 binds the JAG1 gene promoter [Homo sapiens] [Reaction:8878220] RUNX3 binds the NOTCH1 coactivator complex [Homo sapiens] [Reaction:8951428] RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [Homo sapiens] [Reaction:8951676] RUNX3 binds TEADs and YAP1 [Homo sapiens] [Reaction:8952128] RUNX3 binds TP53 [Homo sapiens] [Reaction:8952371] MDM2 binds RUNX3 [Homo sapiens] [Reaction:8952419] SMURFs ubiquitinate RUNX3 [Homo sapiens]
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No pathways have been reviewed or authored by RUNX3 translocates to the nucleus (8937814)