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Details on Person CHFR autoubiquitinates

Class:Id	BlackBoxEvent:8937504
_displayName	CHFR autoubiquitinates
_timestamp	2016-12-30 02:04:06
authored	[InstanceEdit:8937513] May, Bruce, 2016-09-02
catalystActivity	[CatalystActivity:8938684] ubiquitin protein ligase activity of CHFR:Ub:UBE2D2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643189] ubiquitin protein ligase activity of CHFR:Ub:UBE2D2 [nucleoplasm] The auto-ubiquitylation of E3 ubiquitin-protein ligase Chfr at G2 phase is required for accumulation of polo-like kinase 1 and mitotic entry in mammalian cells
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8937514] May, Bruce, 2016-09-02
edited	[InstanceEdit:8937513] May, Bruce, 2016-09-02
input	[Complex:8937511] CHFR:Ub:UBE2D2 [nucleoplasm] [Homo sapiens] [Complex:8937517] Ub:UBE2D2 [nucleoplasm] [Homo sapiens] [Complex:8937517] Ub:UBE2D2 [nucleoplasm] [Homo sapiens] [Complex:8937517] Ub:UBE2D2 [nucleoplasm] [Homo sapiens] [Complex:8937517] Ub:UBE2D2 [nucleoplasm] [Homo sapiens] [Complex:8937517] Ub:UBE2D2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8937516] The auto-ubiquitylation of E3 ubiquitin-protein ligase Chfr at G2 phase is required for accumulation of polo-like kinase 1 and mitotic entry in mammalian cells [LiteratureReference:8942098] The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition [LiteratureReference:8942082] Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity [LiteratureReference:8953876] CHFR is negatively regulated by SUMOylation-mediated ubiquitylation [LiteratureReference:8953873] Analysis of the biochemical role of Lys-11 in polyubiquitin chain formation using quantitative mass spectrometry
modified	[InstanceEdit:8938692] May, Bruce, 2016-09-10 [InstanceEdit:8942117] May, Bruce, 2016-10-08 [InstanceEdit:8942557] May, Bruce, 2016-10-18 [InstanceEdit:8953879] May, Bruce, 2016-12-30 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04
name	CHFR autoubiquitinates
output	[EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8937520] K48polyUb-CHFR [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8852067] UBE2D2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8937515] CHFR binds Ubiquitin:UBE2D2 [Homo sapiens]
regulatedBy	[PositiveRegulation:8937501] Positive regulation by 'STIL [cytosol]'
regulationReference	[RegulationReference:9641536] Positive regulation by 'STIL [cytosol]' The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8937524] R-HSA-8937504.1
summation	[Summation:8942092] The ubiquitin E3 ligase CHFR catalyzes the transfer of ubiqu...
(hasEvent)	[Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins [Homo sapiens]
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No pathways have been reviewed or authored by CHFR autoubiquitinates (8937504)