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Details on Person A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis

Class:IdLiteratureReference:8937040
_displayNameA regulatory interplay between miR-27a and Runx1 during megakaryopoiesis
_timestamp2016-08-26 17:37:24
author[Person:8937034] Ben-Ami, Oren
[Person:8937039] Pencovich, Niv
[Person:8937038] Lotem, Joseph
[Person:3299463] Levanon, Ditsa
[Person:3299451] Groner, Yoram
created[InstanceEdit:8937035] Orlic-Milacic, Marija, 2016-08-26
journalProc. Natl. Acad. Sci. U.S.A.
pages238-43
pubMedIdentifier19114653
titleA regulatory interplay between miR-27a and Runx1 during megakaryopoiesis
volume106
year2009
(literatureReference)[RegulationReference:9641534] Positive gene expression regulation by 'H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[RegulationReference:9642724] Negative gene expression regulation by 'RUNX1 mRNA:miR-27a Nonendonucleolytic RISC [cytosol]' A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis
[Pathway:8934593] Regulation of RUNX1 Expression and Activity [Homo sapiens]
[BlackBoxEvent:8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 [Homo sapiens]
[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
[Reaction:8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene [Homo sapiens]
[BlackBoxEvent:8937097] MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 [Homo sapiens]
[Reaction:8937118] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter [Homo sapiens]
[Reaction:8937134] miR-27a binds RUNX1 mRNA [Homo sapiens]
[Complex:8937133] RUNX1 mRNA:miR-27a Nonendonucleolytic RISC [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis (8937040)
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