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Details on Person Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter

Class:Id	Reaction:8937016
_displayName	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
_doRelease	TRUE
_timestamp	2017-05-09 14:03:51
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity	[CatalystActivity:8937011] histone H3K4 methyltransferase activity of H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643559] histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8937014] Orlic-Milacic, Marija, 2016-08-26
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[Complex:8936977] H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state [LiteratureReference:8937012] Thrombospondin-1 is a transcriptional repression target of PRMT6
modified	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
output	[Complex:8937013] H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens] [Reaction:8934735] PRMT1 arginine-methylates RUNX1 [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8937018] R-HSA-8937016.3
summation	[Summation:8937010] The WDR5-containing histone methyltransferase MLL complex, r...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
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