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Details on Person THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

Class:Id	BlackBoxEvent:8936995
_displayName	THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
_doRelease	TRUE
_timestamp	2017-05-09 14:04:05
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:8936997] Orlic-Milacic, Marija, 2016-08-25
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:8936978] THBS1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state [LiteratureReference:8937012] Thrombospondin-1 is a transcriptional repression target of PRMT6
modified	[InstanceEdit:8937019] Orlic-Milacic, Marija, 2016-08-26 [InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
output	[Complex:549142] THBS1 trimer [platelet alpha granule lumen] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8937000] Positive gene expression regulation by 'H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' [NegativeGeneExpressionRegulation:8937001] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]'
regulationReference	[RegulationReference:9641808] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state [RegulationReference:9642701] Positive gene expression regulation by 'H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936998] R-HSA-8936995.4
summation	[Summation:8936994] The RUNX1:CBFB complex binds the promoter of the THBS1 (TSP-...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
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No pathways have been reviewed or authored by THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (8936995)