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Details on Person RUNX1 and GATA1 bind the promoter of the THBS1 gene

Class:Id	Reaction:8936979
_displayName	RUNX1 and GATA1 bind the promoter of the THBS1 gene
_doRelease	TRUE
_timestamp	2017-05-09 14:03:57
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8936980] Orlic-Milacic, Marija, 2016-08-25
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[DefinedSet:8935716] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] [Homo sapiens] [Complex:8936469] GATA1:ZFPM1 [nucleoplasm] [Homo sapiens] [CandidateSet:5244738] Core MLL complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:352430] KAT2B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8936978] THBS1 gene [nucleoplasm] [Homo sapiens] [Complex:1214200] Nucleosome with H3K4me2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity [LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state [LiteratureReference:8936545] RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation [LiteratureReference:8936554] Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome [LiteratureReference:8936467] Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions
modified	[InstanceEdit:8937009] Orlic-Milacic, Marija, 2016-08-26 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1 and GATA1 bind the promoter of the THBS1 gene
output	[Complex:8936977] H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8865320] CBFB binds RUNX1 [Homo sapiens] [BlackBoxEvent:8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 [Homo sapiens] [Reaction:8934735] PRMT1 arginine-methylates RUNX1 [Homo sapiens] [Reaction:8934742] RUNX1 binds PRMT1 [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936981] R-HSA-8936979.2
summation	[Summation:8936975] The RUNX1:CBFB complex can bind to the promoter of the THBS1...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
(precedingEvent)	[Reaction:8937016] Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by RUNX1 and GATA1 bind the promoter of the THBS1 gene (8936979)