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Details on Person p-BRAF V600K [plasma membrane]

Class:Id	EntityWithAccessionedSequence:8936651
_displayName	p-BRAF V600K [plasma membrane]
_timestamp	2019-05-21 17:17:24
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8936650] Rothfels, Karen, 2016-08-22
crossReference	[DatabaseIdentifier:6802500] COSMIC:COSV56057713
disease	[Disease:1614289] melanoma
endCoordinate	766
hasModifiedResidue	[ReplacedResidue:6802503] L-valine 600 replaced with L-lysine [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
literatureReference	[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
modified	[InstanceEdit:9646281] Rothfels, Karen, 2019-05-21
name	p-BRAF V600K B-RAF
referenceEntity	[ReferenceGeneProduct:58251] UniProt:P15056 BRAF [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936652] R-HSA-8936651.2
startCoordinate	2
(hasMember)	[CandidateSet:8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9900733] Update Tracker - [EntityWithAccessionedSequence:8936651] p-BRAF V600K [plasma membrane] - v70:[modifyName]
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No pathways have been reviewed or authored by p-BRAF V600K [plasma membrane] (8936651)