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Details on Person GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

Class:Id	BlackBoxEvent:8936628
_displayName	GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
_doRelease	TRUE
_timestamp	2017-05-09 14:03:52
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:8936629] Orlic-Milacic, Marija, 2016-08-22
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:8936595] GP1BA gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
modified	[InstanceEdit:8936690] Orlic-Milacic, Marija, 2016-08-22 [InstanceEdit:8936714] Orlic-Milacic, Marija, 2016-08-22 [InstanceEdit:8936999] Orlic-Milacic, Marija, 2016-08-25 [InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
output	[EntityWithAccessionedSequence:55861] GP1BA [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:8936632] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' [PositiveGeneExpressionRegulation:8936634] Positive gene expression regulation by 'H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]'
regulationReference	[RegulationReference:9641599] Positive gene expression regulation by 'H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state [RegulationReference:9642730] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936630] R-HSA-8936628.4
summation	[Summation:8936696] The RUNX1:CBFB complex binds the promoter of the GP1BA (CD42...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
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No pathways have been reviewed or authored by GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (8936628)