Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter

Class:Id	Reaction:8936584
_displayName	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
_doRelease	TRUE
_timestamp	2017-05-09 14:03:55
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity	[CatalystActivity:8936585] histone H3 methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643720] histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8936587] Orlic-Milacic, Marija, 2016-08-22
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[Complex:8935719] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
modified	[InstanceEdit:8936593] Orlic-Milacic, Marija, 2016-08-22 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
output	[Complex:8936586] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:8935730] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter [Homo sapiens] [Reaction:8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936588] R-HSA-8936584.3
summation	[Summation:8936592] The histone arginine methyltransferase PRMT6 asymmetrically ...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8935731] ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (8936584)