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Details on Person NQO2:FAD dimer reduces quinones to hydroquinones

Class:Id	Reaction:8936519
_displayName	NQO2:FAD dimer reduces quinones to hydroquinones
_doRelease	TRUE
_timestamp	2016-10-13 10:14:11
authored	[InstanceEdit:8936524] Jassal, Bijay, 2016-08-22
catalystActivity	[CatalystActivity:8936508] dihydronicotinamide riboside quinone reductase activity of NQO2:FAD dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8936524] Jassal, Bijay, 2016-08-22
edited	[InstanceEdit:8936524] Jassal, Bijay, 2016-08-22
input	[SimpleEntity:8936520] quinone [cytosol] [SimpleEntity:8936516] RFDHN [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8936527] Crystal structure of quinone reductase 2 in complex with resveratrol [LiteratureReference:8936522] Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2 [LiteratureReference:8936563] Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase [LiteratureReference:8936775] NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs [LiteratureReference:8936774] Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy [LiteratureReference:8936804] Cancer chemopreventive activity of resveratrol, a natural product derived from grapes [LiteratureReference:8936770] Wine, alcohol, platelets, and the French paradox for coronary heart disease [LiteratureReference:8936795] Cardiovascular protective effects of resveratrol [LiteratureReference:8936800] Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2
modified	[InstanceEdit:8936558] Jassal, Bijay, 2016-08-22 [InstanceEdit:8936790] Jassal, Bijay, 2016-08-24 [InstanceEdit:8936819] Jassal, Bijay, 2016-08-24 [InstanceEdit:8942335] Jassal, Bijay, 2016-10-13 [InstanceEdit:8942338] Jassal, Bijay, 2016-10-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NQO2:FAD dimer reduces quinones to hydroquinones
output	[SimpleEntity:8936507] hydroquinone [cytosol] [SimpleEntity:8936514] RFNA [cytosol]
regulatedBy	[NegativeRegulation:8936814] Negative regulation by 'resveratrol [cytosol]' [NegativeRegulation:8936815] Negative regulation by 'MLT [cytosol]'
releaseDate	2016-12-12
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8936536] R-HSA-8936519.3
summation	[Summation:8936562] Quinone reductases 1 and 2 (NQO1 and NQO2) comprise the mamm...
(hasEvent)	[Pathway:211945] Phase I - Functionalization of compounds [Homo sapiens]
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No pathways have been reviewed or authored by NQO2:FAD dimer reduces quinones to hydroquinones (8936519)