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Details on Person glutamine + pyruvate => 2-oxoglutaramate + alanine

Class:Id	Reaction:893616
_displayName	glutamine + pyruvate => 2-oxoglutaramate + alanine
_doRelease	TRUE
_timestamp	2024-12-03 20:53:24
authored	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
catalystActivity	[CatalystActivity:893579] L-glutamine:pyruvate transaminase activity of PXLP-KYAT1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643934] L-glutamine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
crossReference	[DatabaseIdentifier:9925792] RHEA:10401
edited	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
input	[SimpleEntity:29472] L-Gln [cytosol] [SimpleEntity:29398] PYR [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:893578] Purification and characterization of kynurenine aminotransferase I from human brain [LiteratureReference:893614] Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K [LiteratureReference:893582] Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase [LiteratureReference:893576] Crystal structure of human kynurenine aminotransferase I
modified	[InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:1004535] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080814] D'Eustachio, P, 2010-11-27 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
name	glutamine + pyruvate => 2-oxoglutaramate + alanine L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine
output	[SimpleEntity:893598] 2OGA [cytosol] [SimpleEntity:29432] L-Ala [cytosol]
precedingEvent	[Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] [Homo sapiens] [Reaction:210439] glutamate uptake by astrocytes [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104507] R-HSA-893616.5
summation	[Summation:893580] CCBL1 (KAT 1) catalyzes the reaction of glutamine and pyruva...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
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No pathways have been reviewed or authored by glutamine + pyruvate => 2-oxoglutaramate + alanine (893616)