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Details on Person Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K

Class:IdLiteratureReference:893614
_displayNameStructural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
_timestamp2010-07-01 21:34:48
author[Person:508546] Han, Q
[Person:508574] Robinson, H
[Person:893606] Cai, T
[Person:893608] Tagle, DA
[Person:508559] Li, J
created[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
journalJ Med Chem
pages2786-93
pubMedIdentifier19338303
titleStructural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
volume52
year2009
(literatureReference)[EntityWithAccessionedSequence:893595] PXLP-K247-KYAT1 [cytosol] [Homo sapiens]
[Complex:893603] PXLP-KYAT1 dimer [cytosol] [Homo sapiens]
[Reaction:893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Homo sapiens]
[Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Homo sapiens]
[Reaction:893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Homo sapiens]
[RegulationReference:9642714] Negative regulation by 'I3LACT, I3PROPA [cytosol]' Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
[CatalystActivityReference:9643870] kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
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