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Details on Person Mature single stranded microRNA miR-675-5p is one of the two...
| Class:Id | Summation:8936073 |
|---|---|
| _displayName | Mature single stranded microRNA miR-675-5p is one of the two... |
| _timestamp | 2016-10-04 14:53:34 |
| created | [InstanceEdit:8936070] Orlic-Milacic, Marija, 2016-08-16 |
| literatureReference | [LiteratureReference:8936069] The imprinted H19 noncoding RNA is a primary microRNA precursor [LiteratureReference:8936054] The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1 |
| modified | [InstanceEdit:8939572] Orlic-Milacic, Marija, 2016-09-20 [InstanceEdit:8941592] Orlic-Milacic, Marija, 2016-10-04 |
| text | Mature single stranded microRNA miR-675-5p is one of the two products of miR-675, which is produced from a precursor long non-coding RNA H19 (Cai and Cullen 2007). miR-675-5p binds to the 3'UTR of RUNX1 mRNA, resulting in decreased RUNX1 mRNA and protein levels. As it decreases RUNX1 mRNA levels, miR-675 is assumed to function as a component of the endonucleolytic RISC, but it is possible that it additionally functions as a component of the nonendonucleolytic RISC. Levels of miR-675 are increased in gastric cancer (Zhuang et al. 2014). |
| (summation) | [Reaction:8936058] miR-675 binds RUNX1 mRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Mature single stranded microRNA miR-675-5p is one of the two... (8936073)
