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Details on Person OCLN (Occludin) gene expression is stimulated by RUNX1

Class:Id	BlackBoxEvent:8935988
_displayName	OCLN (Occludin) gene expression is stimulated by RUNX1
_doRelease	TRUE
_timestamp	2017-05-09 14:03:54
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:8935989] Orlic-Milacic, Marija, 2016-08-15
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:8935981] OCLN gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8935935] MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5
modified	[InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	OCLN (Occludin) gene expression is stimulated by RUNX1
output	[EntityWithAccessionedSequence:2160944] OCLN [cell junction] [Homo sapiens]
precedingEvent	[Reaction:8935980] RUNX1 binds the OCLN gene promoter [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8935993] Positive gene expression regulation by 'RUNX1:CBFB:OCLN gene [nucleoplasm]'
regulationReference	[RegulationReference:9641862] Positive gene expression regulation by 'RUNX1:CBFB:OCLN gene [nucleoplasm]' MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8935991] R-HSA-8935988.4
summation	[Summation:8935990] Binding of the RUNX1:CBFB complex to the promoter of the OCL...
(hasEvent)	[Pathway:8935964] RUNX1 regulates expression of components of tight junctions [Homo sapiens]
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No pathways have been reviewed or authored by OCLN (Occludin) gene expression is stimulated by RUNX1 (8935988)