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Details on Person PXLP-KYAT1 dimer transaminates L-KYN to KYNA

Class:Id	Reaction:893596
_displayName	PXLP-KYAT1 dimer transaminates L-KYN to KYNA
_doRelease	TRUE
_timestamp	2025-02-25 22:17:27
authored	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
catalystActivity	[CatalystActivity:893577] L-kynurenine:2-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643870] kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
crossReference	[DatabaseIdentifier:9929637] RHEA:65561
edited	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
input	[SimpleEntity:29970] L-KYN [cytosol] [SimpleEntity:29406] 2OG [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:893578] Purification and characterization of kynurenine aminotransferase I from human brain [LiteratureReference:893614] Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K [LiteratureReference:893612] The transamination of kynurenine [LiteratureReference:893582] Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase [LiteratureReference:893576] Crystal structure of human kynurenine aminotransferase I
modified	[InstanceEdit:901093] D'Eustachio, P, 2010-07-02 [InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:1004535] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080815] D'Eustachio, P, 2010-11-27 [InstanceEdit:2247552] D'Eustachio, P, 2012-05-14 [InstanceEdit:5649482] Jassal, Bijay, 2014-11-20 [InstanceEdit:5663028] D'Eustachio, Peter, 2015-01-14 [InstanceEdit:8939588] Jassal, Bijay, 2016-09-20 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	PXLP-KYAT1 dimer transaminates L-KYN to KYNA L-kynurenine + 2-oxoglutarate => kynurenate + L-glutamate + H2O
output	[SimpleEntity:893587] KYNA [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:71189] AFMID hydrolyses NFK to L-KYN [Homo sapiens] [Reaction:71188] TDO tetramer dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:198563] IDO1 dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:888614] IDO2 dioxygenates L-Trp to NFK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:2160520] Negative regulation by 'L-Phe [cytosol]' [NegativeRegulation:8939578] Negative regulation by 'I3LACT, I3PROPA [cytosol]'
regulationReference	[RegulationReference:9641942] Negative regulation by 'L-Phe [cytosol]' pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I [RegulationReference:9642714] Negative regulation by 'I3LACT, I3PROPA [cytosol]' Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105738] R-HSA-893596.6
structureModified	[InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27
summation	[Summation:893581] Kynurenine-oxoglutarate transaminase 1 (KYAT1, also known as...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens]
(inferredFrom)	[Reaction:901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA [Homo sapiens]
(replacementInstances)	[_Deleted:9929658] Deletion of instance: 893609
(updatedInstance)	[_UpdateTracker:9776017] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v78:[modifyText] [_UpdateTracker:9782156] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v59:[addRegulator, modifyText] [_UpdateTracker:9788640] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v41:[addRegulator] [_UpdateTracker:9939792] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - v92:[add_removeInput, add_removeOutput, modifyText]
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