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Details on Person ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

Class:Id	BlackBoxEvent:8935731
_displayName	ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
_doRelease	TRUE
_timestamp	2017-11-26 04:14:53
authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:8935734] Orlic-Milacic, Marija, 2016-08-15
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:8935722] ITGA2B gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity [LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
modified	[InstanceEdit:8936405] Orlic-Milacic, Marija, 2016-08-18 [InstanceEdit:8936999] Orlic-Milacic, Marija, 2016-08-25 [InstanceEdit:8941597] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9030299] Orlic-Milacic, Marija, 2017-11-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
output	[EntityWithAccessionedSequence:57578] ITGA2B(32-1039) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene [Homo sapiens] [Reaction:8865320] CBFB binds RUNX1 [Homo sapiens] [Reaction:8934735] PRMT1 arginine-methylates RUNX1 [Homo sapiens] [Reaction:8936584] PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter [Homo sapiens] [Reaction:8935730] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8935733] Positive gene expression regulation by 'H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' [NegativeGeneExpressionRegulation:8935735] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]'
regulationReference	[RegulationReference:9641545] Positive gene expression regulation by 'H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity [RegulationReference:9642363] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
releaseDate	2017-06-12
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8935746] R-HSA-8935731.5
summation	[Summation:8935739] The RUNX1:CBFB complex binds the promoter of the ITGA2B (CD4...
(hasEvent)	[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
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No pathways have been reviewed or authored by ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (8935731)