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Details on Person RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm]

Class:Id	Complex:8935726
_displayName	RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm]
_timestamp	2017-01-11 20:43:59
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8935734] Orlic-Milacic, Marija, 2016-08-15
hasComponent	[CandidateSet:351660] SIN3A,(SIN3B) [nucleoplasm] [Homo sapiens] [Complex:8865330] RUNX1:CBFB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8865293] CBFB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8865295] RUNX1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5226884] PRMT6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205021] HDAC1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8935718] A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia [LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
modified	[InstanceEdit:8936403] Orlic-Milacic, Marija, 2016-08-18 [InstanceEdit:8955517] Orlic-Milacic, Marija, 2017-01-11
name	RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8935742] R-HSA-8935726.1
(activeUnit)	[NegativeGeneExpressionRegulation:8935735] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' [NegativeGeneExpressionRegulation:8936632] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' [NegativeGeneExpressionRegulation:8937001] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' [NegativeGeneExpressionRegulation:8937127] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]'
(hasComponent)	[Complex:8935719] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8936586] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8936600] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8936607] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8936988] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8937024] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8937112] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] [Homo sapiens] [Complex:8937114] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] [Homo sapiens]
(input)	[Reaction:8935730] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter [Homo sapiens] [Reaction:8936599] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter [Homo sapiens] [Reaction:8936989] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter [Homo sapiens] [Reaction:8937118] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter [Homo sapiens]
(output)	[Reaction:8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor [Homo sapiens]
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No pathways have been reviewed or authored by RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (8935726)