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Details on Person Tapasin-ERp57 complex

Class:Id	GO_CellularComponent:8935202
_displayName	Tapasin-ERp57 complex
_timestamp	2016-08-12 19:25:57
accession	0061779
componentOf	[GO_CellularComponent:81623] MHC class I peptide loading complex [Compartment:12045] endoplasmic reticulum membrane [GO_CellularComponent:9470] nuclear outer membrane-endoplasmic reticulum membrane network [GO_CellularComponent:9472] endomembrane system [GO_CellularComponent:6791933] endoplasmic reticulum subcompartment [GO_CellularComponent:70260] endoplasmic reticulum [Compartment:459] cytoplasm [GO_CellularComponent:354] intracellular anatomical structure [GO_CellularComponent:9472] endomembrane system
created	[InstanceEdit:8935181] Weiser, JD
definition	Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role.
instanceOf	[GO_CellularComponent:6791903] membrane protein complex [GO_CellularComponent:258170] protein-containing complex [GO_CellularComponent:357] cellular_component [GO_CellularComponent:9715829] endoplasmic reticulum protein-containing complex [GO_CellularComponent:258170] protein-containing complex [GO_CellularComponent:357] cellular_component
modified	[InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689214] Cook, Justin, 2020-05-15 [InstanceEdit:9715950] Shorser, Solomon, 2021-02-17 [InstanceEdit:9730069] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750511] Weiser, JD, 2021-08-11 [InstanceEdit:9758049] Weiser, JD, 2021-11-08 [InstanceEdit:9767446] Wright, Adam, 2022-02-25 [InstanceEdit:9773560] Weiser, Joel, 2022-05-04 [InstanceEdit:9910546] Weiser, Joel, 2024-05-14 [InstanceEdit:9917761] Weiser, Joel, 2024-08-09 [InstanceEdit:9926777] Weiser, Joel, 2024-11-03 [InstanceEdit:9939260] Weiser, Joel, 2025-02-21 [InstanceEdit:9948590] Weiser, Joel, 2025-05-21 [InstanceEdit:9963890] Weiser, Joel, 2025-08-15 [InstanceEdit:9970828] Weiser, Joel, 2025-10-31 [InstanceEdit:9983368] Weiser, Joel, 2026-02-22 [InstanceEdit:9989188] Weiser, Joel, 2026-05-15
name	Tapasin-ERp57 complex
referenceDatabase	[ReferenceDatabase:1] GO
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No pathways have been reviewed or authored by Tapasin-ERp57 complex (8935202)