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Details on Person UniProt:U3KPV4 A3GALT2
| Class:Id | ReferenceGeneProduct:8934987 |
|---|---|
| _chainChangeLog | chain:1-340 added on Fri August 12 2016 |
| _displayName | UniProt:U3KPV4 A3GALT2 |
| _timestamp | 2025-02-21 20:05:56 |
| chain | chain:1-340 |
| checksum | 129B673AC0DCE037 |
| comment | FUNCTION Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures.CATALYTIC ACTIVITY a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)CATALYTIC ACTIVITY a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + UDP + H(+)CATALYTIC ACTIVITY a globoside Gb3Cer + UDP-alpha-D-galactose = a globoside GalGb3Cer + UDP + H(+)COFACTOR Also found in numerous large vesicles throughout the cytoplasm of the soma.TISSUE SPECIFICITY Expressed in thymus and monocyte derived dendritic cells.DOMAIN The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).SIMILARITY Belongs to the glycosyltransferase 6 family.CAUTION According to a report, the spliced A3GALT2 mRNA is not detected in human tissues (PubMed:18630988). The functional activity of human A3GALT2 tested by expressing a chimeric protein containing the catalytic domain of human A3GALT2 is unable to synthesize isogloboside 3 (iGb3). Futhermore mutagenesis experiments in rat, show that the mutant 'Asn-253' of human A3GALT2 completely eliminates alpha-1,3-galactosyltransferase activity (PubMed:18630988). |
| created | [InstanceEdit:8934940] Weiser, JD |
| description | recommendedName: fullName evidence="9"Alpha-1,3-galactosyltransferase 2 ecNumber evidence="3"2.4.1.87 alternativeName: Isoglobotriaosylceramide synthase shortName evidence="6"iGb3 synthase shortName evidence="6"iGb3S |
| geneName | A3GALT2 A3GALT2P IGBS3S |
| identifier | U3KPV4 |
| isSequenceChanged | FALSE |
| keyword | Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | A3GALT2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987664] ENSEMBL:ENSG00000184389 A3GALT2 [Homo sapiens] |
| secondaryIdentifier | A3LT2_HUMAN |
| sequenceLength | 340 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8942179] A3GALT2 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:U3KPV4 A3GALT2 (8934987)
