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Details on Person Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

Class:Id	Reaction:8934819
_displayName	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
_doRelease	TRUE
_timestamp	2016-10-11 09:21:31
authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
catalystActivity	[CatalystActivity:8934826] endopeptidase activity of Cytoplasmic profilaggrin processing proteases [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8934782] Jupe, Steve, 2016-08-12
edited	[InstanceEdit:8934545] Jupe, Steve, 2016-08-10
input	[EntityWithAccessionedSequence:8849818] FLG(1-4061) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8847665] Caspase-14 protects against epidermal UVB photodamage and water loss [LiteratureReference:8934823] Cuts by caspase-14 control the proteolysis of filaggrin [LiteratureReference:8849795] Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing [LiteratureReference:8934808] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
modified	[InstanceEdit:8934833] Jupe, Steve, 2016-08-12 [InstanceEdit:8936498] Gillespie, Marc E, 2016-08-19 [InstanceEdit:8942227] Jupe, Steve, 2016-10-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
output	[EntityWithAccessionedSequence:6810859] FLG(?-?) [cytosol] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8934829] R-HSA-8934819.3
summation	[Summation:8849790] Filaggrin is initially synthesized as a large, insoluble, hi...
(hasEvent)	[Pathway:6809371] Formation of the cornified envelope [Homo sapiens]
(precedingEvent)	[Reaction:8942224] Filaggrin binds Keratin tonofilament:Desmosome [Homo sapiens]
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No pathways have been reviewed or authored by Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (8934819)