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Details on Person PRMT1 arginine-methylates RUNX1

Class:IdReaction:8934735
_displayNamePRMT1 arginine-methylates RUNX1
_doReleaseTRUE
_timestamp2017-05-12 16:40:15
authored[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
catalystActivity[CatalystActivity:8934749] protein-arginine N-methyltransferase activity of RUNX1:CBFB:PRMT1 [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643897] protein-arginine N-methyltransferase activity of RUNX1:CBFB:PRMT1 [nucleoplasm] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:8934734] Orlic-Milacic, Marija, 2016-08-11
edited[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
input[Complex:8934741] RUNX1:CBFB:PRMT1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
[LiteratureReference:8934732] Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis
modified[InstanceEdit:8934745] Orlic-Milacic, Marija, 2016-08-11
[InstanceEdit:8934753] Orlic-Milacic, Marija, 2016-08-11
[InstanceEdit:8935754] Orlic-Milacic, Marija, 2016-08-15
[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
[InstanceEdit:9006087] Orlic-Milacic, Marija, 2017-05-12
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePRMT1 arginine-methylates RUNX1
output[Complex:8935724] MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent
releaseDate2017-06-12
reviewed[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20
[InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8934737] R-HSA-8934735.3
summation[Summation:8934736] Protein arginine methyltransferase 1 (PRMT1) methylates argi...
(hasEvent)[Pathway:8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function [Homo sapiens]
(precedingEvent)[Reaction:8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene [Homo sapiens]
[Reaction:8936616] RUNX1 and GATA1 bind the promoter of the GP1BA gene [Homo sapiens]
[Reaction:8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene [Homo sapiens]
[Reaction:8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene [Homo sapiens]
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No pathways have been reviewed or authored by PRMT1 arginine-methylates RUNX1 (8934735)
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