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Details on Person Binding of the RUNX1:CBFB complex to the promoter of the LIF...
| Class:Id | Summation:8934716 |
|---|---|
| _displayName | Binding of the RUNX1:CBFB complex to the promoter of the LIF... |
| _timestamp | 2017-01-24 20:51:07 |
| created | [InstanceEdit:8934715] Orlic-Milacic, Marija, 2016-08-11 |
| literatureReference | [LiteratureReference:8934686] The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1 [LiteratureReference:8934719] Leukemia inhibitory factor (LIF) |
| modified | [InstanceEdit:8934720] Orlic-Milacic, Marija, 2016-08-11 [InstanceEdit:8941596] Orlic-Milacic, Marija, 2016-10-04 [InstanceEdit:8941606] Orlic-Milacic, Marija, 2016-10-05 [InstanceEdit:8957310] Orlic-Milacic, Marija, 2017-01-24 |
| text | Binding of the RUNX1:CBFB complex to the promoter of the LIFR gene stimulates LIFR transcription. In contrast, the oncogenic fusion protein RUNX1-ETO, the product of t(8;21) translocation in acute myeloid leukemia (AML), represses transcription of the LIFR gene (Qadi et al. 2016). LIFR encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 (IL6) cytokine family. Signaling by LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola and Babon 2015). |
| (summation) | [BlackBoxEvent:8934690] LIFR gene expression [Homo sapiens] |
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No pathways have been reviewed or authored by Binding of the RUNX1:CBFB complex to the promoter of the LIF... (8934716)
