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Details on Person Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling

Class:Id	Reaction:8933446
_displayName	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
_doRelease	TRUE
_timestamp	2016-08-08 17:40:26
authored	[InstanceEdit:8933395] Rothfels, Karen, 2016-08-04
catalystActivity	[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8933447] Rothfels, Karen, 2016-08-04
edited	[InstanceEdit:8933395] Rothfels, Karen, 2016-08-04
input	[CandidateSet:8933359] DENND1A, DENND1B [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8933343] Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors [LiteratureReference:8854273] TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes [LiteratureReference:8933338] Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
modified	[InstanceEdit:8933628] Rothfels, Karen, 2016-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
output	[CandidateSet:8933377] p-2S DENND1A, DENND1B [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens] [Reaction:2317314] AKT binds PDPK1 [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8933218] Marat, Andrea L, 2016-08-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8933448] R-HSA-8933446.2
summation	[Summation:8933387] In response to insulin signaling, active AKT phosphorylates ...
(hasEvent)	[Pathway:8876198] RAB GEFs exchange GTP for GDP on RABs [Homo sapiens]
(precedingEvent)	[Reaction:8933452] YWHAE dimer binds phosphorylated DENND1 proteins [Homo sapiens]
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No pathways have been reviewed or authored by Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (8933446)