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Details on Person NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)

Class:Id	Reaction:8932765
_displayName	NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)
_doRelease	TRUE
_timestamp	2016-08-10 14:49:53
authored	[InstanceEdit:8932756] May, Bruce, 2016-07-28
catalystActivity	[CatalystActivity:8932761] tRNA (cytidine-N5)-methyltransferase activity of NSUN6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643822] tRNA (cytosine-5-)-methyltransferase activity of NSUN6 [cytosol] NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932764] May, Bruce, 2016-07-28
edited	[InstanceEdit:8932756] May, Bruce, 2016-07-28
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[DefinedSet:8932763] tRNA(Cys,Thr) [cytosol] [Homo sapiens] [SimpleEntity:71284] AdoMet [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8932757] NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs
modified	[InstanceEdit:8932989] Wu, G, 2016-08-01 [InstanceEdit:8932990] Wu, G, 2016-08-01 [InstanceEdit:8932991] Wu, G, 2016-08-01 [InstanceEdit:8934547] May, Bruce, 2016-08-10 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)
output	[DefinedSet:8932759] tRNA(Cys,Thr) containing 5mC72 [cytosol] [Homo sapiens] [SimpleEntity:71285] AdoHcy [cytosol]
precedingEvent	[Reaction:5696807] TRNT1 polymerizes CCA at the 3' end of pre-tRNA [Homo sapiens] [Reaction:5696815] ELAC2 cleaves the 3' end of pre-tRNA [Homo sapiens] [Reaction:6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol [Homo sapiens] [Reaction:6785478] Processed tRNA binds XPOT and RAN:GTP [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934548] Bohnsack, Markus T, 2016-08-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8932774] R-HSA-8932765.3
summation	[Summation:8932768] NSUN6 methylates position 5 of the cytosine ring of cytidine...
(hasEvent)	[Pathway:6782315] tRNA modification in the nucleus and cytosol [Homo sapiens]
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