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Details on Person CK2 phosphorylates NFE2L2

Class:Id	BlackBoxEvent:8932322
_displayName	CK2 phosphorylates NFE2L2
_doRelease	TRUE
_timestamp	2023-08-08 16:11:25
authored	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
catalystActivity	[CatalystActivity:8850941] protein serine/threonine kinase activity of Casein kinase II [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
edited	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
inferredFrom	[BlackBoxEvent:8932375] CK2 phosphorylates Nrf2 [Mus musculus]
input	[SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:201566] NFE2L2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8932340] Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells [LiteratureReference:8932305] Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
modified	[InstanceEdit:8932989] Wu, G, 2016-08-01 [InstanceEdit:8932990] Wu, G, 2016-08-01 [InstanceEdit:8932991] Wu, G, 2016-08-01 [InstanceEdit:9708449] Stephan, Ralf, 2020-11-30 [InstanceEdit:9708934] Stephan, Ralf, 2020-12-03 [InstanceEdit:9713665] Stephan, Ralf, 2021-01-29 [InstanceEdit:9766663] Rothfels, Karen, 2022-02-23 [InstanceEdit:9767010] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767206] Rothfels, Karen, 2022-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841062] Tiwari, Krishna, 2023-08-08
name	CK2 phosphorylates NFE2L2
output	[EntityWithAccessionedSequence:8932311] p-S,T-NFE2L2 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:9762100] MYC- and NICD1-dependent NFE2L2 gene expression [Homo sapiens] [Reaction:9762097] MYC binds the NFE2L2 promoter [Homo sapiens] [Reaction:9762102] NICD1 binds the NFE2L2 promoter [Homo sapiens]
regulatedBy	[PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
regulationReference	[RegulationReference:9708471] Positive regulation by 'ROS [cytosol]' Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
releaseDate	2021-03-23
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8932379] R-HSA-8932322.4
summation	[Summation:8932323] Upon stimulation by oxidative/electrophilic stress, Nuclear ...
(hasEvent)	[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens] [Pathway:9796073] Krishna: NRF2-KEAP1 pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775008] Update Tracker - [BlackBoxEvent:8932322] CK2 phosphorylates NFE2L2 - v80:[add_removeInput, modifyText, removeOutput]
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No pathways have been reviewed or authored by CK2 phosphorylates NFE2L2 (8932322)