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Details on Person PKC phosphorylates NFE2L2

Class:Id	Reaction:8932284
_displayName	PKC phosphorylates NFE2L2
_doRelease	TRUE
_timestamp	2022-02-25 02:58:01
authored	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
catalystActivity	[CatalystActivity:8932367] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PRKCD [cytosol]
catalystActivityReference	[CatalystActivityReference:9643096] protein kinase C activity of PRKCD [cytosol] Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
edited	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
inferredFrom	[Reaction:8932373] PKC phosphorylates Nrf2 [Rattus norvegicus]
input	[SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:201566] NFE2L2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8932342] Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
modified	[InstanceEdit:8932989] Wu, G, 2016-08-01 [InstanceEdit:8932990] Wu, G, 2016-08-01 [InstanceEdit:8932991] Wu, G, 2016-08-01 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9708449] Stephan, Ralf, 2020-11-30 [InstanceEdit:9708934] Stephan, Ralf, 2020-12-03 [InstanceEdit:9713665] Stephan, Ralf, 2021-01-29 [InstanceEdit:9766664] Rothfels, Karen, 2022-02-23 [InstanceEdit:9767049] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767214] Rothfels, Karen, 2022-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PKC phosphorylates NFE2L2 PKC phosphorylates NRF2
output	[EntityWithAccessionedSequence:8932290] p-S40-NFE2L2 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:9762100] MYC- and NICD1-dependent NFE2L2 gene expression [Homo sapiens] [Reaction:9762097] MYC binds the NFE2L2 promoter [Homo sapiens] [Reaction:9762102] NICD1 binds the NFE2L2 promoter [Homo sapiens]
regulatedBy	[PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
regulationReference	[RegulationReference:9708561] Positive regulation by 'ROS [cytosol]' Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
releaseDate	2021-03-23
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8932378] R-HSA-8932284.3
summation	[Summation:8932357] In response to oxidative stress, protein kinase C (PKC) phos...
(hasEvent)	[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774930] Update Tracker - [Reaction:8932284] PKC phosphorylates NFE2L2 - v80:[add_removeInput, modifyText, removeOutput]
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No pathways have been reviewed or authored by PKC phosphorylates NFE2L2 (8932284)