Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9VWE0 dome
| Class:Id | ReferenceGeneProduct:89266 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-1282 added on Sat February 7 2015 |
| _displayName | UniProt:Q9VWE0 dome |
| _timestamp | 2026-02-20 23:04:43 |
| chain | signal peptide:1-23 chain:24-1282 |
| checksum | 22CE960963B17011 |
| comment | FUNCTION Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis.SUBUNIT Interacts with wdp; the interaction promotes internalization of dome and its subsequent lysosomal degradation; thereby reducing JAK/STAT signaling.SUBCELLULAR LOCATION Apicolateral membranes in follical cells.TISSUE SPECIFICITY In stage 11 embryos, tracheal pits show highest expression, at stage 14 high expression is detected in the posterior spiracles, gut and head.DEVELOPMENTAL STAGE Expressed both maternally and zygotically in embryos.PTM Undergoes lysosomal degradation.SIMILARITY Belongs to the type I cytokine receptor family. |
| description | recommendedName: Cytokine receptor alternativeName: Protein domeless |
| geneName | dome CG14226 |
| identifier | Q9VWE0 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Developmental protein Disulfide bond Glycoprotein Membrane Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | dome |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DOME_DROME |
| sequenceLength | 1282 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:206172] DOME [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:206253] Phospho DOME [plasma membrane] [Drosophila melanogaster] |
| (referenceSequence) | [ModifiedResidue:205894] O4'-phospho-L-tyrosine at 966 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9VWE0 dome (89266)
