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Details on Person UniProt:Q61880 Dmc1
| Class:Id | ReferenceGeneProduct:89201 |
|---|---|
| _chainChangeLog | chain:1-340 added on Fri February 6 2015 |
| _displayName | UniProt:Q61880 Dmc1 |
| _timestamp | 2023-11-03 16:55:01 |
| chain | chain:1-340 |
| checksum | 23EAB08D6E668637 |
| comment | FUNCTION Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.SUBUNIT Double stacked ring-shaped homooctamer (By similarity). Interacts with BRCA2 (By similarity). Interacts with the MND1-PSMC3IP heterodimer (PubMed:15834424). Interacts with RAD51AP1; the interaction is direct and stimulates DMC1-mediated homologous recombination (By similarity).SUBCELLULAR LOCATION Testis.DEVELOPMENTAL STAGE In spermatocytes, shows punctate localization along chromosome axes specifically in early meiotic prophase I cells. Foci start to appear from the leptotene stage, reach their greatest number in the zygotene stage, in the early pachytene stage, the DMC1 foci mostly disappeared from autosomes and became restricted to the sex chromosomes.SIMILARITY Belongs to the RecA family. DMC1 subfamily. |
| description | recommendedName: fullName evidence="11"Meiotic recombination protein DMC1/LIM15 homolog |
| geneName | Dmc1 Dmc1h Lim15 |
| identifier | Q61880 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle Chromosome DNA-binding Meiosis Nucleotide-binding Nucleus Reference proteome |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Dmc1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DMC1_MOUSE |
| sequenceLength | 340 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:912509] Dmc1 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q61880 Dmc1 (89201)
