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Details on Person UniProt:Q8TF09 DYNLRB2
| Class:Id | ReferenceGeneProduct:89152 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-96 added on Fri February 6 2015;initiator methionine:1 for 89152 removed on Fri Nov 03 2023;initiator methionine: for 89152 added on Fri Nov 03 2023;initiator methionine: for 89152 removed on Fri Aug 15 2025;initiator methionine:1 for 89152 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8TF09 DYNLRB2 |
| _timestamp | 2025-08-15 21:06:37 |
| chain | initiator methionine:1 chain:2-96 |
| checksum | 526F073855F14330 |
| comment | FUNCTION Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.SUBUNIT Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.SUBCELLULAR LOCATION High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.MISCELLANEOUS Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.SIMILARITY Belongs to the GAMAD family. |
| description | recommendedName: Dynein light chain roadblock-type 2 alternativeName: Dynein light chain 2B, cytoplasmic alternativeName: Roadblock domain-containing protein 2 |
| geneName | DYNLRB2 DNCL2B DNLC2B ROBLD2 |
| identifier | Q8TF09 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Cytoskeleton Direct protein sequencing Dynein Microtubule Motor protein Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DYNLRB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990075] ENSEMBL:ENSG00000168589 DYNLRB2 [Homo sapiens] |
| secondaryIdentifier | DLRB2_HUMAN |
| sequenceLength | 96 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5624869] DYNLRB2 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:5625341] DYNLRB2 [ciliary tip] [Homo sapiens] [EntityWithAccessionedSequence:9969250] DYNLRB2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8TF09 DYNLRB2 (89152)
