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Details on Person Release of GABA at the synapse

Class:Id	Reaction:888589
_displayName	Release of GABA at the synapse
_doRelease	TRUE
_timestamp	2019-12-16 10:50:37
authored	[InstanceEdit:888595] Mahajan, SS, 2010-06-29
catalystActivity	[CatalystActivity:918002] SNARE binding activity of Docked GABA loaded synaptic vesicle [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:888591] Mahajan, SS, 2010-06-29
edited	[InstanceEdit:918263] Mahajan, SS, 2010-08-03
input	[Complex:917774] Docked GABA loaded synaptic vesicle [cytosol] [Homo sapiens] [SimpleEntity:74016] Ca2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:918034] The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids [LiteratureReference:918041] Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A [LiteratureReference:918112] Unconventional GABA release: mechanisms and function
modified	[InstanceEdit:888602] Mahajan, SS, 2010-06-29 [InstanceEdit:918004] Mahajan, SS, 2010-07-30 [InstanceEdit:918007] Mahajan, SS, 2010-07-30 [InstanceEdit:918012] Mahajan, SS, 2010-07-30 [InstanceEdit:918074] Mahajan, SS, 2010-07-31 [InstanceEdit:918135] Mahajan, SS, 2010-08-02 [InstanceEdit:918263] Mahajan, SS, 2010-08-03 [InstanceEdit:936521] Mahajan, SS, 2010-08-23 [InstanceEdit:937316] Mahajan, SS, 2010-08-26 [InstanceEdit:947461] Gillespie, ME, 2010-09-06 [InstanceEdit:947481] Gillespie, ME, 2010-09-07 [InstanceEdit:3065963] Jupe, S, 2013-02-06 [InstanceEdit:3132777] Jassal, Bijay, 2013-02-13 [InstanceEdit:8862681] Gillespie, Marc E, 2016-03-01 [InstanceEdit:9670770] Jassal, Bijay, 2019-12-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Release of GABA at the synapse
output	[EntityWithAccessionedSequence:917998] SLC32A1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:168786] SYT1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210514] STXBP1-1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:210385] CPLX1 [cytosol] [Homo sapiens] [SimpleEntity:352003] GABA [extracellular region] [Complex:9670771] SNARE complex:Ca2+ [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:936512] DNAJC5 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:936508] HSPA8 [plasma membrane] [Homo sapiens] [DefinedSet:947479] PXLP-GAD dimers [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210407] RIMS1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:210461] RAB3A [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:917744] GABA loaded synaptic vesicle Docking and Priming [Homo sapiens] [Reaction:888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen [Homo sapiens] [Reaction:9670745] LTCC pentamer transports Ca2+ from extracellular region to cytosol in neurons [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105279] R-HSA-888589.4
summation	[Summation:918124] GABA synaptic vesicles are fused to the presynaptic terminal...
(hasEvent)	[Pathway:888590] GABA synthesis, release, reuptake and degradation [Homo sapiens] [Pathway:9670172] GABA release cycle [Homo sapiens]
(precedingEvent)	[Reaction:420688] GABAB heterodimeric receptor binds GABA [Homo sapiens] [Reaction:9670774] GABR heteropentamers bind GABA [Homo sapiens] [Reaction:9670780] GABRR pentamers bind GABA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777255] Update Tracker - [Reaction:888589] Release of GABA at the synapse - v72:[addInput, add_removeOutput]
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No pathways have been reviewed or authored by Release of GABA at the synapse (888589)