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Details on Person PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

Class:Id	Reaction:888572
_displayName	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA
_doRelease	TRUE
_timestamp	2019-04-25 10:44:27
authored	[InstanceEdit:888594] Mahajan, SS, 2010-06-29
catalystActivity	[CatalystActivity:888586] glutamate decarboxylase activity of PXLP-K405-GAD1 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:888571] Mahajan, SS, 2010-06-29
edited	[InstanceEdit:918262] Mahajan, SS, 2010-08-03
input	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:888573] Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders [LiteratureReference:918059] Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
modified	[InstanceEdit:888601] Mahajan, SS, 2010-06-29 [InstanceEdit:918072] Mahajan, SS, 2010-07-31 [InstanceEdit:918259] Mahajan, SS, 2010-08-03 [InstanceEdit:936519] Mahajan, SS, 2010-08-23 [InstanceEdit:937314] Mahajan, SS, 2010-08-26 [InstanceEdit:9644714] D'Eustachio, Peter, 2019-04-17 [InstanceEdit:9644832] Jassal, Bijay, 2019-04-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA Synthesis of GABA by GAD1
output	[SimpleEntity:352011] GABA [cytosol] [SimpleEntity:113528] CO2 [cytosol]
releaseDate	2010-09-21
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105084] R-HSA-888572.3
summation	[Summation:888588] GAD1 (GAD67) is evenly spread throughout the neuronal cytopl...
(hasEvent)	[Pathway:888568] GABA synthesis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777678] Update Tracker - [Reaction:888572] PXLP-K405-GAD1 decarboxylates L-Glu to form GABA - v69:[modifyText, removeInput, removeOutput]
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