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Details on Person Iron-sulfur clusters containing 4Fe-4S are assembled from 2F...
| Class:Id | Summation:8878821 |
|---|---|
| _displayName | Iron-sulfur clusters containing 4Fe-4S are assembled from 2F... |
| _timestamp | 2017-02-14 15:37:19 |
| created | [InstanceEdit:8878844] May, Bruce, 2016-07-13 |
| modified | [InstanceEdit:8878858] May, Bruce, 2016-07-13 [InstanceEdit:8961703] May, Bruce, 2017-02-04 [InstanceEdit:8963955] May, Bruce, 2017-02-14 |
| text | Iron-sulfur clusters containing 4Fe-4S are assembled from 2Fe-2S clusters on ISCA1:ISCA2 heterodimers (Banci et al. 2014, Brancaccio et al. 2014, inferred from Saccharomyces cerevisiae in Mühlenhoff et al. 2011). GLRX5:2Fe-2S can donate 2Fe-2S clusters to ISCA1:ISCA2 in vitro (Banci et al. 2014, Brancaccio et al. 2014). It is unclear if other proteins also donate 2Fe-2S clusters. Two conserved C-terminal cysteines of ISCA1:ISCA2 heterodimers extract [2Fe-2S] clusters from GLRX5, forming a ISCA1:ISCA2:GLRX5 intermediate containing two 2Fe-2S clusters (Brancaccio et al. 2017). The physiological electron donor required to convert the two 2Fe-2S clusters bound to the intermediate into a 4Fe-4S cluster is not yet characterized. ISCA1, ISCA2, and IBA57 are required for formation of holoenzymes such as aconitase that contain 4Fe-4S clusters (Sheftel et al. 2012). HSCB (HSC20), the homolog of yeast JAC1, interacts with HSPA9 and appears to facilitate the reaction (Uhrigshardt et al. 2010). |
| (summation) | [Reaction:8878815] Formation of 4Fe-4S cluster on ISCA1:ISCA2 [Homo sapiens] |
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No pathways have been reviewed or authored by Iron-sulfur clusters containing 4Fe-4S are assembled from 2F... (8878821)
