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Details on Person SLC4A4 cotransports Na+ with 3HCO3-

Class:IdReaction:8878664
_displayNameSLC4A4 cotransports Na+ with 3HCO3-
_doReleaseTRUE
_timestamp2025-08-13 18:00:45
authored[InstanceEdit:8878661] Jassal, Bijay, 2016-07-12
catalystActivity[CatalystActivity:8878662] sodium:bicarbonate symporter activity of SLC4A4 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:8878661] Jassal, Bijay, 2016-07-12
edited[InstanceEdit:8878661] Jassal, Bijay, 2016-07-12
input[SimpleEntity:83910] Na+ [cytosol]
[SimpleEntity:111627] HCO3- [cytosol]
[SimpleEntity:111627] HCO3- [cytosol]
[SimpleEntity:111627] HCO3- [cytosol]
literatureReference[LiteratureReference:425585] Cloning and functional expression of a human kidney Na+:HCO3- cotransporter
[LiteratureReference:425594] Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter
[LiteratureReference:425566] Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities
[LiteratureReference:8878658] AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B
modified[InstanceEdit:8878671] Jassal, Bijay, 2016-07-12
[InstanceEdit:8879114] Jassal, Bijay, 2016-07-15
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8934763] Jassal, Bijay, 2016-08-12
[InstanceEdit:8934768] Jassal, Bijay, 2016-08-12
[InstanceEdit:8934769] Jassal, Bijay, 2016-08-12
[InstanceEdit:8935685] Jassal, Bijay, 2016-08-15
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9963189] Stephan, Ralf, 2025-08-13
nameSLC4A4 cotransports Na+ with 3HCO3-
output[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:425425] HCO3- [extracellular region]
[SimpleEntity:425425] HCO3- [extracellular region]
[SimpleEntity:425425] HCO3- [extracellular region]
precedingEvent
regulatedBy[PositiveRegulation:8878657] Positive regulation by 'AHCYL2 [cytosol]'
regulationReference[RegulationReference:9642202] Positive regulation by 'AHCYL2 [cytosol]' AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B
releaseDate2016-09-19
reviewed[InstanceEdit:8934767] D'Eustachio, Peter, 2016-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8921000] R-HSA-8878664.5
summation[Summation:8878659] SLC4A family members 4, 5, 7, and 9 can each couple the tran...
(hasEvent)[Pathway:425381] Bicarbonate transporters [Homo sapiens]
(normalReaction)[FailedReaction:5656219] Defective SLC4A4 does not cotransport Na+ with 3HCO3- [Homo sapiens]
(precedingEvent)[Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens]
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No pathways have been reviewed or authored by SLC4A4 cotransports Na+ with 3HCO3- (8878664)
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