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Details on Person CELF1 binds RNA

Class:Id	Reaction:8878321
_displayName	CELF1 binds RNA
_timestamp	2016-07-15 23:49:07
authored	[InstanceEdit:8878320] May, Bruce, 2016-07-03
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8878282] May, Bruce, 2016-07-04
edited	[InstanceEdit:8878320] May, Bruce, 2016-07-03
input	[EntityWithAccessionedSequence:8878302] CELF1 [cytosol] [Homo sapiens] [DefinedSet:8878298] FOS,TNF mRNA, miR-122 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8878303] CUG-BP binds to RNA substrates and recruits PARN deadenylase [LiteratureReference:8878299] Destabilization of microRNAs in human cells by 3' deadenylation mediated by PARN and CUGBP1 [LiteratureReference:8878295] Analysis of CUGBP1 targets identifies GU-repeat sequences that mediate rapid mRNA decay [LiteratureReference:8878312] Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [LiteratureReference:8878286] The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy [LiteratureReference:8878319] Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy [LiteratureReference:8878300] Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1 [LiteratureReference:8878275] CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	CELF1 binds RNA
output	[Complex:8878277] CELF1:FOS,TNF mRNA, miR-122 [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8886498] R-HSA-8878321.1
summation	[Summation:8878304] CELF1 binds GU-rich elements (EDEN elements) and possibly AU...
(hasEvent)	[Pathway:8878306] CELF1 (CUG-BP) binds and destabilizes mRNA [Homo sapiens]
(precedingEvent)	[Reaction:8878287] CELF1:RNA binds PARN deadenylase [Homo sapiens]
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No pathways have been reviewed or authored by CELF1 binds RNA (8878321)