Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Diagram of Transcriptional regulation by RUNX3
| Class:Id | PathwayDiagram:8878162 |
|---|---|
| _displayName | Diagram of Transcriptional regulation by RUNX3 |
| _timestamp | 2022-08-17 12:01:53 |
| created | [InstanceEdit:8878161] Orlic-Milacic, Marija, 2016-06-30 |
| height | 1436 |
| modified | [InstanceEdit:8878181] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878188] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878210] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878214] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878219] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878232] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878233] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878240] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878241] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878242] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878246] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8878250] Orlic-Milacic, Marija, 2016-06-30 [InstanceEdit:8937802] Orlic-Milacic, Marija, 2016-09-06 [InstanceEdit:8937811] Orlic-Milacic, Marija, 2016-09-06 [InstanceEdit:8937818] Orlic-Milacic, Marija, 2016-09-06 [InstanceEdit:8941866] Orlic-Milacic, Marija, 2016-10-07 [InstanceEdit:8949127] Orlic-Milacic, Marija, 2016-11-19 [InstanceEdit:8949282] Orlic-Milacic, Marija, 2016-11-21 [InstanceEdit:8949316] Orlic-Milacic, Marija, 2016-11-21 [InstanceEdit:8949341] Orlic-Milacic, Marija, 2016-11-21 [InstanceEdit:8949347] Orlic-Milacic, Marija, 2016-11-22 [InstanceEdit:8949360] Orlic-Milacic, Marija, 2016-11-22 [InstanceEdit:8951448] Orlic-Milacic, Marija, 2016-12-02 [InstanceEdit:8951518] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8951524] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8951525] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8951526] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8951534] Orlic-Milacic, Marija, 2016-12-07 [InstanceEdit:8951687] Orlic-Milacic, Marija, 2016-12-08 [InstanceEdit:8951704] Orlic-Milacic, Marija, 2016-12-08 [InstanceEdit:8951776] Orlic-Milacic, Marija, 2016-12-09 [InstanceEdit:8951777] Orlic-Milacic, Marija, 2016-12-09 [InstanceEdit:8951923] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951929] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951933] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951934] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951958] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951974] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8951988] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952001] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952005] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952061] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952076] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952077] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952099] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952105] Orlic-Milacic, Marija, 2016-12-12 [InstanceEdit:8952134] Orlic-Milacic, Marija, 2016-12-13 [InstanceEdit:8952155] Orlic-Milacic, Marija, 2016-12-13 [InstanceEdit:8952236] Orlic-Milacic, Marija, 2016-12-13 [InstanceEdit:8952310] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952370] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952380] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952392] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952404] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952407] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952412] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952413] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952424] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952425] Orlic-Milacic, Marija, 2016-12-14 [InstanceEdit:8952452] Orlic-Milacic, Marija, 2016-12-15 [InstanceEdit:8959890] Orlic-Milacic, Marija, 2017-01-31 [InstanceEdit:9030002] Orlic-Milacic, Marija, 2017-11-24 [InstanceEdit:9030003] Orlic-Milacic, Marija, 2017-11-24 [InstanceEdit:9030196] Orlic-Milacic, Marija, 2017-11-24 [InstanceEdit:9034911] May, Bruce, 2018-01-15 [InstanceEdit:9036791] Matthews, Lisa, 2018-02-08 [InstanceEdit:9632456] Rothfels, Karen, 2018-12-18 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9815382] Orlic-Milacic, Marija, 2022-08-17 |
| representedPathway | [Pathway:8878159] Transcriptional regulation by RUNX3 [Homo sapiens] |
| storedATXML | <?xml version="1.0" encoding="UTF-8"?> <Process nextId="2984" reactomeDiagramId="8878162"> <Properties> <displayName>Diagram of Transcriptional regulation by RUNX3</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="512" reactomeId="70101" position="1178 746" bounds="56 85 2245 1323" textPosition="85 1344" bgColor="250 240 240" lineColor="255 153 102" insets="78 95 2210 1298"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="513" /> <Component id="530" /> <Component id="846" /> <Component id="847" /> <Component id="848" /> <Component id="849" /> <Component id="903" /> <Component id="904" /> <Component id="915" /> <Component id="905" /> <Component id="1299" /> <Component id="1743" /> <Component id="664" /> <Component id="822" /> <Component id="823" /> <Component id="531" /> <Component id="2041" /> <Component id="1390" /> <Component id="2383" /> <Component id="2563" /> <Component id="2769" /> <Component id="2823" /> <Component id="2824" /> <Component id="2825" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="513" reactomeId="7660" position="1259 790" bounds="373 235 1773 1111" textPosition="401 1267" bgColor="250 240 240" lineColor="255 153 102" insets="382 254 1751 1078"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="514" /> <Component id="515" /> <Component id="516" /> <Component id="517" /> <Component id="518" /> <Component id="519" /> <Component id="520" /> <Component id="522" /> <Component id="523" /> <Component id="524" /> <Component id="525" /> <Component id="526" /> <Component id="527" /> <Component id="532" /> <Component id="537" /> <Component id="538" /> <Component id="573" /> <Component id="604" /> <Component id="605" /> <Component id="606" /> <Component id="663" /> <Component id="695" /> <Component id="696" /> <Component id="697" /> <Component id="738" /> <Component id="739" /> <Component id="740" /> <Component id="759" /> <Component id="760" /> <Component id="771" /> <Component id="772" /> <Component id="795" /> <Component id="946" /> <Component id="824" /> <Component id="954" /> <Component id="955" /> <Component id="956" /> <Component id="1124" /> <Component id="1125" /> <Component id="1226" /> <Component id="1228" /> <Component id="1250" /> <Component id="1289" /> <Component id="1328" /> <Component id="1329" /> <Component id="1330" /> <Component id="1328" /> <Component id="1329" /> <Component id="1330" /> <Component id="1389" /> <Component id="1391" /> <Component id="1421" /> <Component id="1429" /> <Component id="1430" /> <Component id="1445" /> <Component id="1446" /> <Component id="1447" /> <Component id="1448" /> <Component id="1449" /> <Component id="1515" /> <Component id="1546" /> <Component id="1547" /> <Component id="1548" /> <Component id="1581" /> <Component id="1604" /> <Component id="1605" /> <Component id="1606" /> <Component id="1607" /> <Component id="1620" /> <Component id="1621" /> <Component id="1623" /> <Component id="1723" /> <Component id="1724" /> <Component id="1725" /> <Component id="1742" /> <Component id="1860" /> <Component id="1861" /> <Component id="1862" /> <Component id="1940" /> <Component id="1941" /> <Component id="1942" /> <Component id="1943" /> <Component id="2038" /> <Component id="2040" /> <Component id="2077" /> <Component id="2188" /> <Component id="2189" /> <Component id="2187" /> <Component id="2241" /> <Component id="2242" /> <Component id="2243" /> <Component id="2270" /> <Component id="2261" /> <Component id="2271" /> <Component id="2262" /> <Component id="2328" /> <Component id="2326" /> <Component id="2327" /> <Component id="2329" /> <Component id="2330" /> <Component id="2382" /> <Component id="2412" /> <Component id="2413" /> <Component id="2414" /> <Component id="2539" /> <Component id="2540" /> <Component id="2538" /> <Component id="2562" /> <Component id="2579" /> <Component id="2710" /> <Component id="2711" /> <Component id="2712" /> <Component id="2713" /> <Component id="2715" /> <Component id="2716" /> <Component id="2768" /> <Component id="2893" /> <Component id="2894" /> <Component id="2895" /> <Component id="2897" /> <Component id="2975" /> <Component id="2976" /> <Component id="2978" /> <Component id="2979" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="515" reactomeId="8865393" position="733 430" bounds="706 419 55 23" textPosition="709 420"> <Properties> <displayName>RUNX3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="516" reactomeId="8865293" position="754 363" bounds="732 352 45 22" textPosition="736 352"> <Properties> <displayName>CBFB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="517" reactomeId="8865463" position="881 440" bounds="849 422 65 36" textPosition="855 423" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="519" reactomeId="8878084" position="917 348" bounds="894 337 46 22" textPosition="894 337"> <Properties> <displayName>ZFHX3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="520" reactomeId="8878120" position="1135 366" bounds="1089 348 92 37" textPosition="1089 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:ZFHX3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="521" reactomeId="170852" position="1006 33" bounds="953 23 106 21" textPosition="959 23" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Dimeric TGFB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="523" reactomeId="3786256" position="989 432" bounds="959 407 60 51" textPosition="958 434"> <Properties> <displayName>CDKN1A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="524" reactomeId="182585" position="1276 439" bounds="1245 427 62 25" textPosition="1247 429"> <Properties> <displayName>CDKN1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="526" reactomeId="8878153" position="597 723" bounds="549 695 97 57" textPosition="553 703" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-2S-SMAD3:p-2S-SMAD3:SMAD4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="527" reactomeId="8878146" position="713 912" bounds="667 878 93 69" textPosition="669 884" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="530" reactomeId="170834" position="701 158" bounds="620 122 163 72" textPosition="627 136"> <Properties> <displayName>Signaling by TGF-beta Receptor Complex</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="538" reactomeId="8878180" position="1151 523" bounds="1082 498 138 50" textPosition="1084 499" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:CDKN1A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="605" reactomeId="8878209" position="906 682" bounds="882 657 49 51" textPosition="886 684"> <Properties> <displayName>JAG1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="606" reactomeId="8878200" position="1034 790" bounds="991 771 87 38" textPosition="991 774" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:JAG1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="664" reactomeId="157098" position="968 1400" bounds="943 1385 51 31" textPosition="950 1390"> <Properties> <displayName>JAG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="696" reactomeId="1604462" position="570 1040" bounds="527 1015 87 50" textPosition="532 1016" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NOTCH1 Coactivator Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="697" reactomeId="8878230" position="857 1132" bounds="805 1100 104 64" textPosition="803 1115" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:NOTCH1 Coactivator Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="739" reactomeId="2197548" position="606 1120" bounds="579 1095 55 51" textPosition="585 1122"> <Properties> <displayName>HES1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="740" reactomeId="8878239" position="764 1204" bounds="700 1179 128 51" textPosition="700 1181" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:NOTCH1 coactivator complex:HES1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="760" reactomeId="4396364" position="466 1160" bounds="419 1127 95 67" textPosition="418 1131" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NOTCH1 Coactivator Complex:HES1 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="772" reactomeId="210825" position="663 1270" bounds="638 1260 50 20" textPosition="644 1260"> <Properties> <displayName>HES1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="822" reactomeId="1980143" position="667 1399" bounds="610 1371 114 57" textPosition="623 1378"> <Properties> <displayName>Signaling by NOTCH1</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="847" reactomeId="1810408" position="104 95" bounds="35 79 138 33" textPosition="44 85"> <Properties> <displayName>MyrG-p-Y419-SRC</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.12681159420289856" relativeY="0.0" label="My" trackId="0" reactomeId="1810396" /> <org.gk.render.RenderableFeature relativeX="0.2536231884057971" relativeY="0.0" label="P" trackId="0" reactomeId="1810398" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="848" reactomeId="8937797" position="162 173" bounds="136 162 53 22" textPosition="138 162" /> <org.gk.render.RenderableComplex id="849" reactomeId="8937795" position="89 256" bounds="27 238 125 36" textPosition="27 239" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MyrG-p-Y419-SRC:RUNX3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="904" reactomeId="113592" position="142 302" bounds="124 288 37 29" textPosition="127 292"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="905" reactomeId="8937805" position="140 488" bounds="96 476 88 24" textPosition="101 477"> <Properties> <displayName>p-Y-RUNX3</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.5833333333333334" label="P" description="Tyr" trackId="0" reactomeId="8937803" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="915" reactomeId="29370" position="169 388" bounds="150 376 38 24" textPosition="153 377"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableGene id="955" reactomeId="8948433" position="1720 783" bounds="1690 758 61 51" textPosition="1698 785"> <Properties> <displayName>RORC gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="956" reactomeId="8949278" position="1902 726" bounds="1857 708 91 36" textPosition="1860 709" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB:RORC gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1125" reactomeId="8949306" position="1984 802" bounds="1956 791 57 22" textPosition="1956 791"> <Properties> <displayName>RORC-2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1228" reactomeId="8949328" position="1563 356" bounds="1518 332 90 49" textPosition="1520 332" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB:ITGAL gene,(ITGA4 gene)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1289" reactomeId="8949354" position="1403 344" bounds="1361 323 85 42" textPosition="1361 326"> <Properties> <displayName>ITGAL gene,(ITGA4 gene)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1299" reactomeId="8949353" position="1411 95" bounds="1382 76 58 38" textPosition="1385 77"> <Properties> <displayName>ITGAL,(ITGA4)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1329" reactomeId="8951429" position="1248 807" bounds="1181 788 135 38" textPosition="1186 791" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1330" reactomeId="8951432" position="1347 866" bounds="1293 840 108 52" textPosition="1294 843" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1389" reactomeId="8853953" position="1506 888" bounds="1480 863 52 51" textPosition="1479 890"> <Properties> <displayName>CCND1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="1390" reactomeId="68328" position="2229 952" bounds="2204 941 51 22" textPosition="2204 941"> <Properties> <displayName>CCND1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1391" reactomeId="8853944" position="1580 952" bounds="1533 928 95 48" textPosition="1537 927" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTNNB1:TCF7L2,LEF1:CCND1 Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1430" reactomeId="8951439" position="1450 818" bounds="1402 801 96 35" textPosition="1408 801" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CTNNB1:TCF7L2,LEF1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1445" reactomeId="8951514" position="1341 930" bounds="1284 913 115 34" textPosition="1288 912" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CTNNB1:TCF7L2,(LEF1)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1447" reactomeId="2127254" position="1072 1054" bounds="1046 1029 53 51" textPosition="1054 1056"> <Properties> <displayName>MYC gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1448" reactomeId="4411378" position="1064 947" bounds="1010 930 108 34" textPosition="1010 929" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TCF7L1/TCF7L2/LEF1:CTNNB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1449" reactomeId="4411387" position="1284 995" bounds="1228 971 113 49" textPosition="1230 971" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1515" reactomeId="8951528" position="1175 896" bounds="1128 871 94 50" textPosition="1129 872" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:TCF7L2,(LEF1,TCF7L1)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1547" reactomeId="8951678" position="1285 629" bounds="1220 611 131 36" textPosition="1220 612" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1548" reactomeId="8951679" position="1668 671" bounds="1608 646 120 50" textPosition="1618 647" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1605" reactomeId="8869639" position="1468 576" bounds="1428 565 81 22" textPosition="1428 565" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>TEADs:YAP1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1606" reactomeId="5649937" position="1578 517" bounds="1550 492 56 51" textPosition="1556 519"> <Properties> <displayName>CTGF gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1607" reactomeId="8951697" position="1858 569" bounds="1811 551 94 36" textPosition="1816 552" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TEADs:YAP1:CTGF gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1621" reactomeId="561148" position="1773 386" bounds="1752 375 42 22" textPosition="1753 375"> <Properties> <displayName>CTGF</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1623" reactomeId="2032762" position="1809 508" bounds="1749 497 120 22" textPosition="1749 498" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TEAD:WWTR1(TAZ)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1724" reactomeId="8951912" position="1842 879" bounds="1811 854 63 51" textPosition="1816 881"> <Properties> <displayName>RUNX1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1725" reactomeId="8951907" position="1980 846" bounds="1935 827 90 38" textPosition="1937 830" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB:RUNX1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="1743" reactomeId="8935779" position="2211 860" bounds="2164 838 95 45" textPosition="2167 850"> <Properties> <displayName>RUNX1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="1861" reactomeId="381325" position="1558 1053" bounds="1535 1042 47 22" textPosition="1535 1042"> <Properties> <displayName>EP300</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1862" reactomeId="8951952" position="1869 992" bounds="1823 974 92 36" textPosition="1826 975" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1941" reactomeId="113560" position="1995 1045" bounds="1968 1030 54 30" textPosition="1969 1034"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1942" reactomeId="8951959" position="1913 1173" bounds="1842 1155 142 36" textPosition="1842 1156" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ac-K94,K171-RUNX3:CBFB:EP300</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1943" reactomeId="2485002" position="2000 1120" bounds="1971 1104 58 32" textPosition="1973 1109"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="2040" reactomeId="8951976" position="1575 1169" bounds="1501 1150 148 39" textPosition="1504 1154" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ac-K94,K171-RUNX3:CBFB:EP300:BRD2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2041" reactomeId="8951978" position="1679 1402" bounds="1644 1389 71 27" textPosition="1646 1395" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>KRAS:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2077" reactomeId="8951995" position="1772 1224" bounds="1735 1207 75 35" textPosition="1735 1207" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BRD2 homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2188" reactomeId="113832" position="1581 1114" bounds="1556 1103 51 22" textPosition="1556 1103" /> <org.gk.render.RenderableComplex id="2189" reactomeId="8952057" position="1321 1160" bounds="1267 1136 108 49" textPosition="1273 1136" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2242" reactomeId="351581" position="1225 1114" bounds="1200 1103 51 22" textPosition="1200 1103"> <Properties> <displayName>HDAC4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2243" reactomeId="8952063" position="1106 1171" bounds="1045 1146 122 50" textPosition="1045 1147" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2262" reactomeId="8952072" position="1415 1272" bounds="1367 1254 97 36" textPosition="1367 1255" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:CBFB:CCND1:HDAC4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2270" reactomeId="113518" position="1176 1241" bounds="1154 1228 45 26" textPosition="1159 1230"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2271" reactomeId="427486" position="1272 1270" bounds="1235 1255 75 30" textPosition="1239 1259"> <Properties> <displayName>CH3COO-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2327" reactomeId="8952092" position="1762 1288" bounds="1702 1263 121 50" textPosition="1702 1263" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="2329" reactomeId="3200017" position="1877 1288" bounds="1846 1263 63 51" textPosition="1846 1290"> <Properties> <displayName>CDKN2A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2330" reactomeId="8952078" position="2030 1231" bounds="1969 1199 123 64" textPosition="1969 1200" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="2383" reactomeId="3209107" position="2214 1278" bounds="2176 1253 76 50" textPosition="2185 1260"> <Properties> <displayName>p14ARF mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="2413" reactomeId="3209194" position="738 295" bounds="703 278 70 34" textPosition="707 277" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2414" reactomeId="8952123" position="902 288" bounds="853 270 99 36" textPosition="858 271" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:TP53 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2539" reactomeId="8870688" position="504 822" bounds="473 797 62 51" textPosition="473 824"> <Properties> <displayName>BCL2L11 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2540" reactomeId="8952225" position="466 936" bounds="396 904 141 64" textPosition="399 919" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2563" reactomeId="2976673" position="321 862" bounds="291 851 60 22" textPosition="291 851"> <Properties> <displayName>BCL2L11</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2579" reactomeId="199305" position="641 822" bounds="617 811 49 22" textPosition="617 811"> <Properties> <displayName>FOXO3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2711" reactomeId="6804933" position="512 363" bounds="465 345 95 36" textPosition="465 346" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S166,S188-MDM2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2712" reactomeId="8952373" position="527 481" bounds="466 463 122 37" textPosition="467 465" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX3:p-S166,S188-MDM2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2715" reactomeId="8952387" position="487 651" bounds="420 632 134 39" textPosition="426 634"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.11940298507462686" relativeY="0.0" label="U" trackId="0" reactomeId="8952383" /> <org.gk.render.RenderableFeature relativeX="0.23880597014925373" relativeY="0.0" label="U" trackId="0" reactomeId="8952384" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2716" reactomeId="1629813" position="574 568" bounds="543 557 62 22" textPosition="547 557"> <Properties> <displayName>p14ARF</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2769" reactomeId="8952400" position="278 650" bounds="211 631 134 38" textPosition="217 632"> <Properties> <displayName>PolyUb-K94,K148-RUNX3</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.11940298507462686" relativeY="0.0" label="U" trackId="0" reactomeId="8952383" /> <org.gk.render.RenderableFeature relativeX="0.23880597014925373" relativeY="0.0" label="U" trackId="0" reactomeId="8952384" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2824" reactomeId="113595" position="260 786" bounds="248 775 25 22" textPosition="248 775" /> <org.gk.render.RenderableComplex id="2825" reactomeId="177750" position="168 718" bounds="116 707 104 22" textPosition="116 708" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>26S proteasome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2894" reactomeId="8952417" position="679 588" bounds="646 570 67 37" textPosition="652 571"> <Properties> <displayName>PolyUb-RUNX3</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.23880597014925373" relativeY="0.0" label="U" trackId="0" reactomeId="8952415" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2895" reactomeId="178205" position="734 511" bounds="711 500 47 22" textPosition="711 500"> <Properties> <displayName>SMURF</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="2897" reactomeId="381325" position="740 550" bounds="717 539 47 22" textPosition="717 539" /> <org.gk.render.RenderableGene id="2976" reactomeId="8952436" position="1352 570" bounds="1318 545 69 51" textPosition="1318 572"> <Properties> <displayName>SPP1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="2977" reactomeId="215967" position="1629 62" bounds="1611 51 37 22" textPosition="1611 51"> <Properties> <displayName>SPP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2978" reactomeId="188379" position="1332 1086" bounds="1315 1075 34 22" textPosition="1315 1075"> <Properties> <displayName>MYC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2979" reactomeId="68524" position="591 523" bounds="579 512 25 22" textPosition="579 512"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="514" reactomeId="8865454" points="785 432, 800 443, 846 441" position="800 443" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="515" points="764 431" /> <Input id="516" points="758 377" /> </Inputs> <Outputs> <Output id="517" /> </Outputs> <Properties> <displayName>CBFB binds RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="518" reactomeId="8878117" points="964 390, 1024 361, 1086 363" position="1024 361" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="519" points="929 362" /> <Input id="515" points="764 425" /> </Inputs> <Outputs> <Output id="520" /> </Outputs> <Activators> <Activator id="521" points="1006 47" /> </Activators> <Properties> <displayName>RUNX3 binds ZFHX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="522" reactomeId="8878130" points="1028 409, 1138 435, 1242 438" position="1138 435" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="523" /> </Inputs> <Outputs> <Output id="524" /> </Outputs> <Activators> <Activator id="520" points="1135 388" /> </Activators> <Properties> <displayName>CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="525" reactomeId="8878143" points="803 642, 735 771, 718 875" position="735 771" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="515" points="739 445, 793 536" /> <Input id="526" points="649 703" /> </Inputs> <Outputs> <Output id="527" /> </Outputs> <Properties> <displayName>RUNX3 binds SMAD3 and SMAD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="531" interactionType="Activate" points="980 47, 786 125" position="883 86" lineWidth="2.0"> <Inputs> <Input id="521" /> </Inputs> <Outputs> <Output id="530" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="532" interactionType="Activate" points="694 197, 602 692" position="648 444" lineWidth="2.0"> <Inputs> <Input id="530" /> </Inputs> <Outputs> <Output id="526" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="537" reactomeId="8878178" points="1022 483, 1035 504, 1079 511" position="1035 504" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="527" points="729 875, 864 591" /> <Input id="523" points="1028 409" /> </Inputs> <Outputs> <Output id="538" /> </Outputs> <Properties> <displayName>The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="573" reactomeId="8878186" points="1028 409, 1151 465, 1242 445" position="1151 465" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="523" /> </Inputs> <Outputs> <Output id="524" /> </Outputs> <Activators> <Activator id="538" points="1151 495" /> </Activators> <Properties> <displayName>CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="604" reactomeId="8878193" points="912 603, 991 674, 1026 768" position="991 674" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="515" points="744 445" /> <Input id="605" points="940 659" /> </Inputs> <Outputs> <Output id="606" /> </Outputs> <Properties> <displayName>RUNX3 binds the JAG1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="663" reactomeId="8878212" points="940 659, 943 790, 967 1382" position="943 790" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="605" /> </Inputs> <Outputs> <Output id="664" /> </Outputs> <Inhibitors> <Inhibitor id="606" points="988 790" /> </Inhibitors> <Properties> <displayName>JAG1 gene expression is inhibited by RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="695" reactomeId="8878220" points="909 946, 857 1055, 857 1097" position="857 1055" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="696" points="617 1027" /> <Input id="515" points="741 445, 827 556" /> </Inputs> <Outputs> <Output id="697" /> </Outputs> <Properties> <displayName>RUNX3 binds the NOTCH1 coactivator complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="738" reactomeId="8878237" points="747 1124, 740 1145, 753 1176" position="740 1145" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="739" points="643 1097" /> <Input id="697" points="802 1128" /> </Inputs> <Outputs> <Output id="740" /> </Outputs> <Properties> <displayName>RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="759" reactomeId="4396347" points="594 1098, 578 1104, 517 1136" position="578 1104" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="696" points="580 1068" /> <Input id="739" points="643 1097" /> </Inputs> <Outputs> <Output id="760" /> </Outputs> <Properties> <displayName>NOTCH1 Coactivator Complex binds HES1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="771" reactomeId="1980047" points="643 1097, 640 1175, 660 1257" position="640 1175" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="739" /> </Inputs> <Outputs> <Output id="772" /> </Outputs> <Activators> <Activator id="760" points="517 1164" /> </Activators> <Properties> <displayName>NOTCH1 stimulates HES1 transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="795" reactomeId="8878243" points="643 1097, 666 1181, 663 1257" position="666 1181" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="739" /> </Inputs> <Outputs> <Output id="772" /> </Outputs> <Inhibitors> <Inhibitor id="740" points="697 1188" /> </Inhibitors> <Properties> <displayName>HES1 gene transcription is inhibited by RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="823" interactionType="Activate" points="940 1399, 727 1399" position="833 1399" lineWidth="2.0"> <Inputs> <Input id="664" /> </Inputs> <Outputs> <Output id="822" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="824" interactionType="Activate" points="642 1368, 494 1197" position="568 1282" lineWidth="2.0"> <Inputs> <Input id="822" /> </Inputs> <Outputs> <Output id="760" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="846" reactomeId="8937792" points="97 132, 96 201, 91 235" position="96 201" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="847" points="100 115" /> <Input id="848" points="144 159" /> </Inputs> <Outputs> <Output id="849" /> </Outputs> <Properties> <displayName>RUNX3 binds SRC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="903" reactomeId="8937807" points="81 312, 74 365, 83 423" position="74 365" lineWidth="1.0"> <Inputs> <Input id="849" points="86 277" /> <Input id="904" points="121 305" /> </Inputs> <Outputs> <Output id="905" points="129 473" /> <Output id="915" points="147 395" /> <Output id="847" points="32 93, 9 93, 8 401" /> </Outputs> <Catalysts> <Catalyst id="849" points="74 277, 38 320" /> </Catalysts> <Properties> <displayName>SRC phosphorylates RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="946" reactomeId="8937814" points="192 180, 420 245, 713 416" position="420 245" lineWidth="1.0"> <Inputs> <Input id="848" /> </Inputs> <Outputs> <Output id="515" /> </Outputs> <Inhibitors> <Inhibitor id="847" points="176 103, 421 136" /> </Inhibitors> <Activators> <Activator id="521" points="950 37, 558 70" /> </Activators> <Properties> <displayName>RUNX3 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="954" reactomeId="8949276" points="1677 753, 1787 727, 1854 726" position="1787 727" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="517" points="903 461, 1190 687" /> <Input id="955" points="1760 760" /> </Inputs> <Outputs> <Output id="956" /> </Outputs> <Properties> <displayName>RUNX3:CBFB binds the RORC gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1124" reactomeId="8949301" points="1760 760, 1901 800, 1953 801" position="1901 800" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="955" /> </Inputs> <Outputs> <Output id="1125" /> </Outputs> <Activators> <Activator id="956" points="1901 747" /> </Activators> <Properties> <displayName>RORC gene expression is stimulated by RUNX3:CBFB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1226" reactomeId="8949335" points="1406 499, 1452 464, 1537 384" position="1452 464" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1289" points="1403 371" /> <Input id="517" points="912 461, 1134 586" /> </Inputs> <Outputs> <Output id="1228" /> </Outputs> <Properties> <displayName>RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1250" reactomeId="8949343" points="1403 317, 1405 277, 1410 120" position="1405 277" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1289" /> </Inputs> <Outputs> <Output id="1299" /> </Outputs> <Activators> <Activator id="1228" points="1515 333" /> </Activators> <Properties> <displayName>ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1328" reactomeId="8951428" points="1153 755, 1325 764, 1341 837" position="1325 764" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1329" points="1213 785" /> <Input id="515" points="747 445" /> </Inputs> <Outputs> <Output id="1330" /> </Outputs> <Properties> <displayName>RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1421" reactomeId="8951443" points="1541 865, 1580 890, 1857 932, 2201 950" position="1580 890" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1389" /> </Inputs> <Outputs> <Output id="1390" /> </Outputs> <Activators> <Activator id="1391" points="1580 925" /> </Activators> <Properties> <displayName>Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1429" reactomeId="8951442" points="1451 863, 1454 933, 1530 944" position="1454 933" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1430" points="1450 839" /> <Input id="1389" points="1541 865" /> </Inputs> <Outputs> <Output id="1391" /> </Outputs> <Inhibitors> <Inhibitor id="1445" points="1402 931" /> </Inhibitors> <Properties> <displayName>CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1446" reactomeId="4411367" points="1131 982, 1175 986, 1225 990" position="1175 986" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1447" points="1108 1031" /> <Input id="1448" points="1096 967" /> </Inputs> <Outputs> <Output id="1449" /> </Outputs> <Inhibitors> <Inhibitor id="1515" points="1175 924" /> </Inhibitors> <Properties> <displayName>TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1546" reactomeId="8951676" points="1168 647, 1292 685, 1465 684, 1605 674" position="1465 684" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1547" points="1217 639" /> <Input id="515" points="749 445, 1030 641" /> </Inputs> <Outputs> <Output id="1548" /> </Outputs> <Properties> <displayName>RUNX3 binds TEADs and YAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1581" reactomeId="4411357" points="1108 1031, 1287 1052, 1317 1072" position="1287 1052" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1447" /> </Inputs> <Outputs> <Output id="2978" /> </Outputs> <Activators> <Activator id="1449" points="1285 1023" /> </Activators> <Properties> <displayName>TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1604" reactomeId="8951695" points="1634 556, 1649 554, 1808 565" position="1649 554" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1605" points="1515 571" /> <Input id="1606" points="1615 494" /> </Inputs> <Outputs> <Output id="1607" /> </Outputs> <Inhibitors> <Inhibitor id="1548" points="1663 643" /> </Inhibitors> <Properties> <displayName>TEADs:YAP1 binds CTGF gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1620" reactomeId="1989766" points="1615 494, 1672 428, 1749 394" position="1672 428" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1606" /> </Inputs> <Outputs> <Output id="1621" /> </Outputs> <Activators> <Activator id="1605" points="1483 559" /> <Activator id="1623" points="1790 494" /> </Activators> <Properties> <displayName>Expression of CTGF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1723" reactomeId="8951910" points="1807 855, 1843 829, 1932 840" position="1843 829" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1724" points="1883 856" /> <Input id="517" points="902 461, 1189 701" /> </Inputs> <Outputs> <Output id="1725" /> </Outputs> <Properties> <displayName>RUNX3 binds the RUNX1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1742" reactomeId="8951926" points="1883 856, 1970 910, 2161 869" position="1970 910" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1724" /> </Inputs> <Outputs> <Output id="1743" /> </Outputs> <Inhibitors> <Inhibitor id="1725" points="1977 868" /> </Inhibitors> <Properties> <displayName>RUNX1 gene expression is inhibited by RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1860" reactomeId="8951951" points="1523 1003, 1727 988, 1820 990" position="1727 988" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1861" points="1550 1039" /> <Input id="517" points="896 461, 1119 713, 1150 852, 1235 855, 1234 959, 1424 961" /> </Inputs> <Outputs> <Output id="1862" /> </Outputs> <Properties> <displayName>RUNX3 binds EP300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1940" reactomeId="8951966" points="1904 1038, 1907 1081, 1903 1114" position="1907 1081" lineWidth="1.0"> <Inputs> <Input id="1941" stoichiometry="2" points="1965 1042" /> <Input id="1862" points="1882 1013" /> </Inputs> <Outputs> <Output id="1942" points="1909 1152" /> <Output id="1943" stoichiometry="2" points="1968 1118" /> </Outputs> <Catalysts> <Catalyst id="1862" points="1865 1013, 1857 1060" /> </Catalysts> <Activators> <Activator id="521" points="1062 32, 2437 22, 2443 1076" /> </Activators> <Properties> <displayName>EP300 acetylates RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2038" reactomeId="8951977" points="1741 1166, 1684 1163, 1652 1164" position="1684 1163" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1942" points="1839 1170" /> <Input id="2077" points="1762 1204" /> </Inputs> <Outputs> <Output id="2040" /> </Outputs> <Activators> <Activator id="2041" points="1679 1386" /> </Activators> <Properties> <displayName>Acetylated RUNX3 binds to BRD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2187" reactomeId="8952058" points="1496 1129, 1493 1102, 1461 1091" position="1493 1102" lineWidth="1.0"> <Inputs> <Input id="2040" points="1536 1147" /> <Input id="2188" points="1553 1118" /> </Inputs> <Outputs> <Output id="1861" points="1532 1062" /> <Output id="2189" points="1370 1133" /> </Outputs> <Properties> <displayName>CCND1 binds RUNX3 and displaces EP300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2241" reactomeId="8952062" points="1206 1142, 1157 1122, 1132 1143" position="1157 1122" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2242" points="1217 1128" /> <Input id="2189" points="1264 1151" /> </Inputs> <Outputs> <Output id="2243" /> </Outputs> <Properties> <displayName>CCND1 recruits HDAC4 to RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2261" reactomeId="8952069" points="1202 1181, 1226 1186, 1258 1197" position="1226 1186" lineWidth="1.0"> <Inputs> <Input id="2243" points="1170 1177" /> <Input id="2270" stoichiometry="2" points="1181 1225" /> </Inputs> <Outputs> <Output id="2077" points="1732 1222" /> <Output id="2271" stoichiometry="2" points="1269 1252" /> <Output id="2262" points="1377 1251" /> </Outputs> <Catalysts> <Catalyst id="2243" points="1170 1166, 1205 1163" /> </Catalysts> <Properties> <displayName>HDAC4 deacetylates RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2326" reactomeId="8952081" points="1913 1244, 1936 1237, 1966 1234" position="1936 1237" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2327" points="1829 1270" /> <Input id="2329" points="1918 1265" /> </Inputs> <Outputs> <Output id="2330" /> </Outputs> <Properties> <displayName>RUNX proteins bind the p14-ARF promoter at the CDKN2A locus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2328" points="1607 1192, 1721 1257" position="1664 1224" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2040" /> </Inputs> <Outputs> <Output id="2327" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2382" reactomeId="8952101" points="1918 1265, 2027 1296, 2173 1281" position="2027 1296" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2329" /> </Inputs> <Outputs> <Output id="2383" /> </Outputs> <Activators> <Activator id="2330" points="2028 1266" /> </Activators> <Properties> <displayName>p14-ARF transcription is stimulated by RUNX proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2412" reactomeId="8952128" points="848 374, 829 329, 869 309" position="829 329" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2413" points="761 315" /> <Input id="515" points="756 416" /> </Inputs> <Outputs> <Output id="2414" /> </Outputs> <Properties> <displayName>RUNX3 binds TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2538" reactomeId="8952226" points="601 863, 574 870, 518 901" position="574 870" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2539" points="544 799" /> <Input id="527" points="664 891" /> <Input id="2579" points="630 836" /> </Inputs> <Outputs> <Output id="2540" /> </Outputs> <Properties> <displayName>RUNX3 binds the BCL2L11 (BIM) gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2562" reactomeId="8952232" points="544 799, 441 799, 341 848" position="441 799" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2539" /> </Inputs> <Outputs> <Output id="2563" /> </Outputs> <Activators> <Activator id="2540" points="460 901" /> </Activators> <Properties> <displayName>BCL2L11 (BIM) gene transcription is stimulated by RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2710" reactomeId="8952371" points="537 409, 526 434, 526 460" position="526 434" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2711" points="521 384" /> <Input id="515" points="703 427" /> </Inputs> <Outputs> <Output id="2712" /> </Outputs> <Properties> <displayName>MDM2 binds RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2713" reactomeId="8952382" points="540 545, 507 558, 498 583" position="507 558" lineWidth="1.0"> <Inputs> <Input id="2712" points="530 503" /> <Input id="2979" stoichiometry="6" points="573 528" /> </Inputs> <Outputs> <Output id="2715" points="490 629" /> <Output id="2711" points="462 369, 415 376, 418 578" /> </Outputs> <Catalysts> <Catalyst id="2712" points="500 503, 481 513" /> </Catalysts> <Inhibitors> <Inhibitor id="2716" points="540 563" /> </Inhibitors> <Properties> <displayName>MDM2 polyubiquitinates RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2768" reactomeId="8952399" points="417 651, 381 652, 348 651" position="381 652" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2715" /> </Inputs> <Outputs> <Output id="2769" /> </Outputs> <Properties> <displayName>Polyubiquitinated RUNX3 translocates to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2823" reactomeId="8952408" points="273 672, 262 717, 260 769" position="262 717" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2769" /> </Inputs> <Outputs> <Output id="2824" stoichiometry="6" /> </Outputs> <Catalysts> <Catalyst id="2825" points="223 717" /> </Catalysts> <Properties> <displayName>Polyubiquitinated RUNX3 is degraded by the proteasome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2893" reactomeId="8952419" points="703 472, 673 525, 677 567" position="673 525" lineWidth="1.0"> <Inputs> <Input id="2979" stoichiometry="3" points="610 517" /> <Input id="515" points="724 445" /> </Inputs> <Outputs> <Output id="2894" /> </Outputs> <Catalysts> <Catalyst id="2895" points="705 516" /> </Catalysts> <Inhibitors> <Inhibitor id="2897" points="714 541" /> </Inhibitors> <Properties> <displayName>SMURFs ubiquitinate RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2975" reactomeId="8952442" points="1396 547, 1475 533, 1482 501, 1635 389, 1629 76" position="1482 501" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2976" /> </Inputs> <Outputs> <Output id="2977" /> </Outputs> <Activators> <Activator id="517" points="907 461, 1130 607" /> </Activators> <Properties> <displayName>SPP1 gene expression is stimulated by RUNX3</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
| width | 2451 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Diagram of Transcriptional regulation by RUNX3 (8878162)
